Related Experiment Video
Updated: Jun 20, 2026

2-Vessel Occlusion/Hypotension: A Rat Model of Global Brain Ischemia
Published on: June 22, 2013
Prolonged dependence of ischemic penumbra on induced hypertension
1Department of Neurology and Stroke Program, University of California, Davis Medical Center, Sacramento, CA 95817, USA. piero.verro@ucdmc.ucdavis.edu
Background:
Pharmacological elevation of blood pressure in acute stroke due to large artery occlusion may enhance collateral blood flow and salvage penumbral tissue. The duration of viability of human penumbral tissue under such circumstances is unclear.
Objective:
To describe a patient presenting with acute middle cerebral artery occlusion treated with induced hypertension who had prolonged survival of penumbral tissue with subsequent infarct extension after pressor agents were withdrawn.
Conclusions:
Enhanced collateral flow by elevation of blood pressure may result in prolonged survival of the ischemic penumbra which remains dependent on persistent use of pressor agents.
More Related Videos
07:49Simultaneous Photothrombosis and Fiber Photometry to Induce and Monitor Ischemic Stroke in Behaving Mice
Published on: November 14, 2025
09:48Quantification of Neurovascular Protection Following Repetitive Hypoxic Preconditioning and Transient Middle Cerebral Artery Occlusion in Mice
Published on: May 4, 2015
Related Concept Videos
Ischemic Stroke ll: Pathophysiology
Hypertension II: Pathophysiology
Hypertension III: Clinical Manifestations and Diagnostic Studies
Hypertension and Regulation of Blood Pressure
Increased Intracranial Pressure ll: Pathophysiology
Ischemic Stroke l: Introduction