Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Antifungal Agents01:15

Antifungal Agents

Amphotericin B is a broad-spectrum antifungal agent that exploits structural differences between fungal and mammalian cell membranes. Its amphipathic structure—featuring a hydrophobic polyene-lactone ring and a hydrophilic region containing mycosamine and carboxylic acid groups—enables selective binding to ergosterol, a sterol predominantly found in fungal plasma membranes. This selective interaction underlies the drug’s antifungal activity, although weak binding to cholesterol contributes to...
Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses a challenge in...
Antiprotozoal Agents01:21

Antiprotozoal Agents

Leishmaniasis is a widespread parasitic disease caused by several Leishmania species. It affects millions of people each year and remains a major public health problem in endemic regions. First-line treatment relies on pentavalent antimonials, including meglumine antimoniate and sodium stibogluconate. Even so, how these drugs work has not been fully clear, especially their interaction with parasite-specific biochemical pathways. One key target is trypanothione reductase (TR), an enzyme that...
Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

Pharmacokinetics in Pediatric Patients: Drug Distribution

Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight, compared...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Variation of caffeine use in late preterm infants in U.S. NICUs over time: A 12-year cohort study.

Journal of perinatology : official journal of the California Perinatal Association·2026
Same author

Population Pharmacokinetics and Dosing Simulations of Pentobarbital in the Pediatric Population.

Journal of clinical pharmacology·2026
Same author

Conducting multicenter trials through the trial innovation network comprehensive consultation.

Contemporary clinical trials·2026
Same author

Population Pharmacokinetics and Exposure-Safety Analysis of Furosemide in Preterm Infants.

Journal of clinical pharmacology·2026
Same author

Evaluating the duration of post-discontinuation therapeutic ampicillin exposures in preterm infants.

Journal of perinatology : official journal of the California Perinatal Association·2026
Same author

Pharmacokinetics, safety and preliminary efficacy study of montelukast in critically ill infants with developing bronchopulmonary dysplasia (PRISM).

Contemporary clinical trials communications·2026

Related Experiment Video

Updated: Jun 20, 2026

Broth Microdilution In Vitro Screening: An Easy and Fast Method to Detect New Antifungal Compounds
08:54

Broth Microdilution In Vitro Screening: An Easy and Fast Method to Detect New Antifungal Compounds

Published on: February 14, 2018

Pediatric antifungal agents.

Michael Cohen-Wolkowiez1, Cassandra Moran, Daniel K Benjamin

  • 1Department of Pediatrics, Duke University, Duke Clinical Research Institute, Durham, NC 27715, USA.

Current Opinion in Infectious Diseases
|September 11, 2009
PubMed
Summary
This summary is machine-generated.

New antifungal drugs show promise for children, but more research is needed. Current dosing relies on adult data, highlighting the need for pediatric-specific antifungal studies to ensure safe and effective treatment.

More Related Videos

Quantifying the Antifungal Activity of Peptides Against Candida albicans
06:45

Quantifying the Antifungal Activity of Peptides Against Candida albicans

Published on: January 13, 2023

Related Experiment Videos

Last Updated: Jun 20, 2026

Broth Microdilution In Vitro Screening: An Easy and Fast Method to Detect New Antifungal Compounds
08:54

Broth Microdilution In Vitro Screening: An Easy and Fast Method to Detect New Antifungal Compounds

Published on: February 14, 2018

Quantifying the Antifungal Activity of Peptides Against Candida albicans
06:45

Quantifying the Antifungal Activity of Peptides Against Candida albicans

Published on: January 13, 2023

Area of Science:

  • Pediatric Infectious Diseases
  • Pharmacology
  • Mycology

Background:

  • Invasive fungal infections pose a significant threat to immunocompromised children.
  • Recent advancements have expanded the range of available antifungal therapies.
  • Understanding the use of these agents in pediatric populations is critical.

Purpose of the Study:

  • To review current literature on antifungal agents in pediatric patients.
  • To highlight progress in pediatric antifungal pharmacokinetics and safety.
  • To identify gaps in knowledge and future research needs.

Main Methods:

  • Literature review of recent studies on antifungal agents.
  • Focus on pediatric data, including pharmacokinetics and safety.
  • Analysis of newer agents, such as echinocandins.

Main Results:

  • Limited pediatric-specific data exists for many antifungal agents.
  • Progress has been made in understanding the pharmacokinetics and safety of newer antifungals in children.
  • Echinocandins represent a class with emerging pediatric data.

Conclusions:

  • Current antifungal dosing in children often extrapolates from adult data.
  • Childhood developmental changes significantly impact drug pharmacokinetics.
  • Pediatric-focused clinical trials are essential for establishing evidence-based dosing guidelines.