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[Differential expression of guanylin in colorectal cancer]
Yin-bo Chen1, Yu-ping Zhu, Hai-yang Feng
1Department of Colorectal Oncology, Zhejiang Cancer Hospital, Hangzhou, China.
Objective:
To investigate the expression of guanylin in colorectal cancer.
Methods:
The expression of guanylin was examined by RT-PCR and semiquantitative analysis in 20 cases of colorectal cancer, and its relationship with clinical characteristics was analyzed.
Results:
The positive expression of guanylin in normal tissue (80%, 16/20) was significantly higher than that in tumor tissue (35%, 7/20) (P<0.01). The same result was found in the semiquantitative analysis of 14 cases with differential expression. Differential expression of guanylin in colorectal cancer was associate with TNM stage (P<0.05), not with sex, Borrmann type and degree of differentiation (all P>0.05).
Conclusion:
There is differential expression of guanylin in colorectal cancer, and this kind of differential expression is associated with tumor TNM stage.
