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Peptic ulcer in children.

T M Tsang1, H Saing, C K Yeung

  • 1Department of Surgery, University of Hong Kong, Queen Mary Hospital.

Journal of Pediatric Surgery
|July 1, 1990
PubMed
Summary
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Pediatric peptic ulcers treated with H2-blockers showed varied healing times. Higher acid output correlated with longer treatment duration, and a significant recurrence rate was observed post-healing.

Area of Science:

  • Pediatric Gastroenterology
  • Gastrointestinal Surgery

Background:

  • Primary peptic ulcers are diagnosed in children.
  • Duodenal ulcers were more common than prepyloric ulcers.

Purpose of the Study:

  • To evaluate the efficacy of H2-blocker therapy in children with primary peptic ulcers.
  • To identify factors associated with treatment success and recurrence.

Main Methods:

  • Retrospective analysis of 39 children diagnosed with primary peptic ulcers between 1983 and 1989.
  • H2-blocker therapy was administered to 36 patients, with healing assessed endoscopically.
  • Basal acid output (BAO) and maximal acid output (MAO) were measured.

Main Results:

  • 33 of 36 patients completed H2-blocker therapy.

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  • 49% healed within 6 weeks; 51% required multiple courses.
  • Higher BAO and MAO were significantly associated with longer healing times (P < .05 and P < .005).
  • 10 patients experienced recurrent ulcers within a mean follow-up of 1.8 years (35% 1-year recurrence rate).
  • Five patients required surgery for complications (obstruction, perforation, bleeding).

    • Conclusions:

    • H2-blocker therapy is effective for pediatric peptic ulcers, but some patients require prolonged treatment.
    • Elevated gastric acid output may predict slower healing.
    • Recurrence and complications necessitate long-term monitoring and management strategies.