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Metabolomic analysis of Echinacea spp. by 1H nuclear magnetic resonance spectrometry and multivariate data analysis
Michel Frédérich1, Céline Jansen, Pascal de Tullio
1Laboratory of Pharmacognosy, Natural and Synthetic Drug Research Center, University of Liège, Avenue de l'Hópital, 1, B36, B-4000 Liège, Belgium. M.Frederich@ulg.ac.be
Introduction:
The genus Echinacea (Asteraceae) comprises about 10 species originally distributed in North America. Three species are very well known as they are used worldwide as medicinal plants: Echinacea purpurea, E. pallida, E. angustifolia.
Objective:
To discriminate between these three Echinacea species and E. simulata by (1)H NMR-based metabolomics.
Methodology:
(1)H NMR and multivariate analysis techniques were applied to diverse Echinacea plants including roots and aerial parts, authentic plants, commercial plants and commercial dry extracts.
Results:
Using the (1)H NMR metabolomics, it was possible, without previous evaporation or separation steps, to obtain a metabolic fingerprint to distinguish between species.
Conclusion:
A clear distinction between the three pharmaceutical species was possible and some useful metabolites were identified.
