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[Significance of flumazenil in acute benzodiazepine poisoning]
F del Busto Prado1, A Alvarez García, A Ibarra Peláez
1Servicio de Urgencias, Hospital Covadonga, Oviedo.
Medicina Clinica
|April 28, 1990
Abstract:
Thirty-five patients over 14 years of age were evaluated, with the common feature of benzodiazepine poisoning, either as a single drug or associated with others and/or with ethanol, and who had a Glasgow score lower than 10 at admission. These patients were treated with flumazenil as a competitive antagonist drug. The results were very satisfactory. Subsequently, the possible relationship between the effect of flumazenil and the pharmacokinetic benzodiazepine profile was evaluated, and a significant relationship between the half life and the degree of resedation of the patients was found.