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An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
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Protein Networks

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Related Experiment Video

Updated: Jun 20, 2026

Mapping Bacterial Functional Networks and Pathways in Escherichia Coli using Synthetic Genetic Arrays

Mapping Bacterial Functional Networks and Pathways in Escherichia Coli using Synthetic Genetic Arrays

Published on: November 12, 2012

Interaction networks: lessons from large-scale studies in yeast.

Gerard Cagney¹

¹Conway Institute, University College Dublin, Belfield, Dublin, Ireland. gerard.cagney@ucd.ie

|September 11, 2009

Summary

Saccharomyces cerevisiae, a simple eukaryotic model, offers extensive gene and protein data. This organism pioneered computational analysis techniques for genetic and physical interaction networks.

Area of Science:

Cell Biology
Systems Biology
Genomics

Background:

Saccharomyces cerevisiae serves as a fundamental eukaryotic model organism in cell biology research.
Its genetic tractability facilitates the development of large-scale analysis methods, particularly in reverse genetics.
Extensive genomewide datasets are available for yeast, surpassing those of other organisms.

Purpose of the Study:

To provide a concise overview of physical and genetic interaction networks in Saccharomyces cerevisiae.
To highlight significant experimental and computational advancements pioneered in yeast.

Main Methods:

Survey of existing literature on yeast physical and genetic interaction networks.
Review of computational and experimental methodologies applied to yeast data.

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High-throughput Yeast Plasmid Overexpression Screen

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Last Updated: Jun 20, 2026

Mapping Bacterial Functional Networks and Pathways in Escherichia Coli using Synthetic Genetic Arrays

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Main Results:

Yeast has been instrumental in developing numerous computational analysis techniques.
Significant progress has been made in mapping yeast's physical and genetic interaction networks.

Conclusions:

Saccharomyces cerevisiae is a crucial model for understanding complex biological networks.
The organism's data has driven innovation in systems biology and computational analysis.