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Resonance Rayleigh-scattering spectral method for the determination of some aminoglycoside antibiotics using CdTe
Lei Wang1, Juanjuan Peng, Zhengwen Liu
1Key Laboratory on Luminescence and Real-time Analysis, Ministry of Education, School of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, People's Republic of China.
Abstract:
A novel method is used for the determination of some aminoglycoside antibiotics (AGs) such as etimicin (ETM), isepamicin (ISP) and amikacin (AMK). It is based on the resonance Rayleigh scattering (RRS) intensities enhanced by AGs-induced CdTe quantum dots aggregation. Under the optimum conditions, the increments in RRS intensity were directly proportional to the concentration of AGs in certain ranges. At the same time, the second-order scattering, the frequency-doubling scattering and the frequency-trebling scattering intensities were also enhanced and their increments were proportional to the concentration of AGs. Among them, the RRS method had the highest sensitivity; the linear ranges and detection limits for ETM, ISP and AMK were 0.085-7.2, 0.0067-1.2, 0.017-6.0 and 0.025, 0.0051, 0.0020 μg mL(-1) . This method was applied to the measurement of AGs in human serum and urine with satisfactory results. In addition, the reaction mechanism and the reasons for the enhancement of RRS are discussed using fluorescence, RRS, transmission electron microscope technology and quantum chemistry method.
