Isolation and structural elucidation of euryjanicins B-D, proline-containing cycloheptapeptides from the Caribbean marine sponge Prosuberites laughlini
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Brunilda Vera1, Jan Vicente, Abimael D Rodríguez
1Department of Chemistry, University of Puerto Rico, U. P. R. Station, San Juan, PR 00931-3346.
Journal of Natural Products
|September 12, 2009
Abstract:
Three new cyclic peptides, euryjanicins B (2), C (3), and D (4), have been isolated from the Puerto Rican marine sponge Prosuberites laughlini, and the structures were elucidated by chemical degradation, ESIMS/MS, and extensive 2D NMR methods. When tested against the National Cancer Institute 60 tumor cell line panel, all of the purified isolates displayed weak cytotoxicity.
