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Soluble tumor necrosis factor receptor-1 in preterm infants with chronic lung disease
Miho Sato1, Masaaki Mori, Shigeru Nishimaki
1Department of Pediatrics, Yokohama City University School of Medicine, Yokohama, Kanagawa, Japan. gacha0108@yahoo.co.jp
Insights
Infants with chronic lung disease have higher serum levels of soluble tumor necrosis factor receptor-1 (sTNFR-1) post-delivery. These elevated sTNFR-1 levels persist for 28 days, suggesting inflammation
Area of Science:
- Neonatal Medicine
- Pediatric Pulmonology
- Inflammatory Biomarkers
Background:
- Inflammation is a key factor in the development of chronic lung disease in preterm infants.
- Understanding inflammatory markers can provide insights into disease pathogenesis.
Purpose of the Study:
- To investigate temporal changes in serum soluble tumor necrosis factor receptor-1 (sTNFR-1) levels.
- To compare sTNFR-1 levels in infants with and without chronic lung disease.
Main Methods:
- Serum sTNFR-1 levels were measured in preterm infants at multiple time points post-delivery (birth, 7, 14, 21, 28 days).
- A cohort of 10 infants with chronic lung disease was compared to 18 infants without the condition.
Main Results:
- Infants with chronic lung disease exhibited significantly higher serum sTNFR-1 levels at birth compared to controls.
- This significant difference in sTNFR-1 levels persisted throughout the 28-day study period.
Conclusions:
- Elevated sTNFR-1 suggests a role for inflammation in chronic lung disease.
- Persistent inflammation from prenatal to postnatal periods may contribute to disease onset.
Background:
It is clear that inflammation plays an important role in developing chronic lung disease in preterm infants. The purpose of the present study is to investigate changes of serum soluble tumor necrosis factor receptor-1 levels over time in infants with chronic lung disease.
Methods:
The serum levels of soluble tumor necrosis factor receptor-1 were measured after delivery, and at 7, 14, 21 and 28 days of age in 10 infants with chronic lung disease and in 18 infants without chronic lung disease.
Results:
The serum level of soluble tumor necrosis factor receptor-1 was significantly higher in infants with chronic lung disease than in infants without chronic lung disease after delivery. The differences between these two groups remained up to 28 days of age.
Conclusion:
Prenatal inflammation with persistence into postnatal inflammation may be involved in the onset of chronic lung disease.
