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Gene Evolution - Fast or Slow?

Gene Evolution - Fast or Slow?

The genomes of eukaryotes are punctuated by long stretches of sequence which do not code for proteins or RNAs. Although some of these regions do contain crucial regulatory sequences, the vast majority of this DNA serves no known function. Typically, these regions of the genome are the ones in which the fastest change, in evolutionary terms, is observed, because there is typically little to no selection pressure acting on these regions to preserve their sequences.
In contrast, regions which code...

Gene Evolution - Fast or Slow?

Gene Evolution - Fast or Slow?

The genomes of eukaryotes are punctuated by long stretches of sequence which do not code for proteins or RNAs. Although some of these regions do contain crucial regulatory sequences, the vast majority of this DNA serves no known function. Typically, these regions of the genome are the ones in which the fastest change, in evolutionary terms, is observed, because there is typically little to no selection pressure acting on these regions to preserve their sequences.
In contrast, regions which code...

Genome Annotation and Assembly

Genome Annotation and Assembly

The genome refers to all of the genetic material in an organism. It can range from a few million base pairs in microbial cells to several billion base pairs in many eukaryotic organisms. Genome assembly refers to the process of taking the DNA sequencing data and putting it all back together in a correct order to create a close representation of the original genome. This is followed by the identification of functional elements on the newly assembled genome, a process called genome annotation.

Gene Families

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Gene families consist of groups of genes proposed to have originated from a common ancestor. Typically these arise through events in which a gene or genes are mistakenly duplicated during cell division. Unlike their parent genes (which are subject to selection pressure to maintain function), these gene copies do not need to preserve their sequences and may evolve at a relatively faster rate.
Occasionally these regions can be adapted to take on new roles within the organism, becoming novel genes...

Gene Families

Gene Families

Gene families consist of groups of genes proposed to have originated from a common ancestor. Typically these arise through events in which a gene or genes are mistakenly duplicated during cell division. Unlike their parent genes (which are subject to selection pressure to maintain function), these gene copies do not need to preserve their sequences and may evolve at a relatively faster rate.
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Genomics

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Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...

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Related Experiment Video

Updated: Jun 20, 2026

A Web Tool for Generating High Quality Machine-readable Biological Pathways

A Web Tool for Generating High Quality Machine-readable Biological Pathways

Published on: February 8, 2017

QuickGO: a web-based tool for Gene Ontology searching.

David Binns¹, Emily Dimmer, Rachael Huntley

¹European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB101SD, UK. dbinns@ebi.ac.uk

Bioinformatics (Oxford, England)

|September 12, 2009

Summary

This summary is machine-generated.

QuickGO is a web-based tool for browsing the Gene Ontology (GO) and its annotations. Redevelopment enhances functionality with bulk data downloads and GO slim set generation.

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Published on: December 22, 2017

Area of Science:

Bioinformatics
Molecular Biology

Background:

The Gene Ontology (GO) provides a standardized vocabulary for describing gene and gene product functions.
Accessing and analyzing GO annotations is crucial for biological research.
QuickGO has been a widely used tool for GO exploration.

Purpose of the Study:

To introduce the redeveloped QuickGO web-based tool.
To highlight new features for enhanced GO annotation data retrieval and analysis.
To provide information on the tool's accessibility and implementation.

Main Methods:

QuickGO is implemented using JavaScript, Ajax, and HTML.
The tool supports all major web browsers.
It offers online querying and downloadable software under the Apache 2 license.

Main Results:

The redeveloped QuickGO facilitates easy browsing of GO and its associated annotations.
New functionalities include bulk downloads of GO annotation data with extensive filtering capabilities.
Users can generate GO slim sets tailored to specific research needs.

Conclusions:

The enhanced QuickGO tool offers improved capabilities for accessing and analyzing Gene Ontology data.
Its user-friendly interface and advanced features support diverse bioinformatics applications.
QuickGO remains a valuable resource for the research community, with expanded functionality for data mining.