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BDNF val66met polymorphism influences motor system function in the human brain.

Stephanie A McHughen1, Paul F Rodriguez, Jeffrey A Kleim

  • 1Department of Anatomy and Neurobiology, University of California, Irvine, CA 92697, USA.

Cerebral Cortex (New York, N.Y. : 1991)
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The brain-derived neurotrophic factor (BDNF) val(66)met polymorphism impacts motor system function and learning. This genetic variation is linked to altered brain plasticity and poorer motor skill acquisition and retention.

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Area of Science:

  • Neuroscience
  • Genetics
  • Motor Control

Background:

  • Brain-derived neurotrophic factor (BDNF) is crucial for neuronal plasticity and repair.
  • The common BDNF val(66)met polymorphism is associated with reduced activity-dependent BDNF release.

Purpose of the Study:

  • To investigate the impact of the BDNF val(66)met polymorphism on human motor system function.
  • To evaluate its effects on short-term brain plasticity and motor learning.

Main Methods:

  • Functional magnetic resonance imaging (fMRI) was used to assess brain activation during motor tasks.
  • A driving-based motor learning task was employed in an independent cohort.

Main Results:

  • Subjects with the BDNF polymorphism exhibited smaller sensorimotor network activation volumes.
  • Altered brain activation patterns and reduced plasticity were observed post-training in carriers.
  • The polymorphism group showed increased errors and poorer retention in motor learning.

Conclusions:

  • The BDNF val(66)met polymorphism is associated with distinct motor system function and plasticity.
  • This genetic variation negatively affects short-term motor learning and memory consolidation.