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Related Concept Videos

Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Cancers Originate from Somatic Mutations in a Single Cell02:21

Cancers Originate from Somatic Mutations in a Single Cell

Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
Cancers Originate from Somatic Mutations in a Single Cell02:21

Cancers Originate from Somatic Mutations in a Single Cell

Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...

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Related Experiment Video

Updated: Jun 20, 2026

Ex Vivo Culture of Primary Human Fallopian Tube Epithelial Cells
11:46

Ex Vivo Culture of Primary Human Fallopian Tube Epithelial Cells

Published on: May 9, 2011

Ovarian cancer pathogenesis: a model in evolution.

Alison M Karst1, Ronny Drapkin

  • 1Department of Medical Oncology, Center for Molecular Oncologic Pathology, Dana-Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA.

Journal of Oncology
|September 12, 2009
PubMed
Summary

Ovarian cancer lacks effective early detection methods due to its heterogeneity. Recent research suggests the fallopian tube fimbria may be a key origin site for ovarian carcinomas, advancing our understanding of this deadly disease.

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Heterotypic Three-dimensional In Vitro Modeling of Stromal-Epithelial Interactions During Ovarian Cancer Initiation and Progression
12:42

Heterotypic Three-dimensional In Vitro Modeling of Stromal-Epithelial Interactions During Ovarian Cancer Initiation and Progression

Published on: August 28, 2012

Related Experiment Videos

Last Updated: Jun 20, 2026

Ex Vivo Culture of Primary Human Fallopian Tube Epithelial Cells
11:46

Ex Vivo Culture of Primary Human Fallopian Tube Epithelial Cells

Published on: May 9, 2011

Heterotypic Three-dimensional In Vitro Modeling of Stromal-Epithelial Interactions During Ovarian Cancer Initiation and Progression
12:42

Heterotypic Three-dimensional In Vitro Modeling of Stromal-Epithelial Interactions During Ovarian Cancer Initiation and Progression

Published on: August 28, 2012

Area of Science:

  • Gynecologic Oncology
  • Cancer Pathogenesis
  • Molecular Biology

Background:

  • Ovarian cancer is a leading cause of cancer death with no effective early detection.
  • Ovarian carcinomas are highly heterogeneous, complicating diagnosis and treatment.
  • The early development of ovarian cancer remains poorly understood.

Purpose of the Study:

  • To provide an overview of current ovarian cancer pathogenesis models.
  • To highlight recent findings on the origin of ovarian carcinomas.
  • To discuss the implications for developing screening modalities.

Main Methods:

  • Review of existing literature on ovarian cancer.
  • Analysis of recent research implicating specific anatomical sites.
  • Synthesis of genetic and etiological data.

Main Results:

  • Ovarian carcinomas exhibit significant diversity in morphology, genetics, and behavior.
  • The fallopian tube fimbria is increasingly implicated as a potential origin site.
  • Understanding heterogeneity is crucial for effective treatment strategies.

Conclusions:

  • Current models of ovarian cancer pathogenesis are evolving.
  • The fallopian tube is a critical area for further investigation in ovarian cancer research.
  • Continued research into ovarian cancer genetics and etiology is essential for improving early detection and treatment.