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[Lipoprotein-x determination in children beyond an age of 6 months (author's transl)]
Insights
Abnormal lipoprotein (LP-X) is common in infants under 24 weeks but less frequent in older children. LP-X in older children has clinical significance similar to adults.
Area of Science:
- Biochemistry
- Pediatric Medicine
- Clinical Chemistry
Context:
- Abnormal lipoprotein (LP-X) is frequently detected in premature and newborn infants up to 24 weeks postpartum.
- Previous studies have established the clinical significance of LP-X in adults.
Purpose:
- To evaluate the presence and clinical significance of LP-X in children older than 6 months.
- To compare LP-X detection rates in different pediatric age groups.
Summary:
- A study analyzed 250 sera from 158 infants across various age groups for LP-X.
- LP-X was detected in 85.7% of infants younger than 24 weeks.
- In children aged 24 weeks to 14 years, LP-X was detected in 16.35% of cases.
Impact:
- LP-X detection rates decrease significantly after 24 weeks of age.
- The clinical significance of LP-X in older children mirrors that observed in adults.
- This study highlights the changing prevalence and consistent clinical relevance of LP-X in pediatric populations.
Abstract:
In premature and newborn infants an abnormal lipoprotein (LP-X) was almost regularly detectable by examination up to the 24th week after deliver. The aim of the submitted study was to evaluate LP-X results in children older than 6 months. 250 sera of 158 infants of all age groups were tested for presence of LP-X. The frequency of LP-X positive results was 85.7% in the group of infants younger than 24 weeks (91 samples of 45 infants were tested) whereas in the group of infants of an age between 24 weeks and 14 years (159 samples of 113 children were tested) 16.35% positive results were obtained. LP-X positive results showed the same clinical significance in the second group of children as it was demonstrated in adults elsewhere.