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Related Concept Videos

Regulation of Metabolism01:19

Regulation of Metabolism

Cellular needs and conditions vary from cell to cell and change within individual cells over time. For example, the required enzymes and energetic demands of stomach cells are different from those of fat storage cells, skin cells, blood cells, and nerve cells. Furthermore, a digestive cell works much harder to process and break down nutrients during the time that closely follows a meal compared with many hours after a meal. As these cellular demands and conditions vary, so do the amounts and...
Liver Physiology01:30

Liver Physiology

The liver, an essential organ in the human body, performs over 200 vital functions that can be broadly categorized into metabolic, hematological, endocrine regulation, and bile production.
Metabolic Regulation:
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Regulation of the Unfolded Protein Response01:31

Regulation of the Unfolded Protein Response

Inositol-requiring kinase one or IRE1 is the most conserved eukaryotic unfolded protein response (UPR) receptor. It is a type I transmembrane protein kinase receptor with a distinctive site-specific RNase activity. As the binding mechanics of the misfolded proteins with the N-terminal domain of IRE-1 are unclear, three binding models — direct, indirect, and allosteric -- are proposed for receptor activation. Nevertheless, it is known that once a misfolded protein associates with IRE1, it...
mTOR Signaling and Cancer Progression03:03

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Sulfur Assimilation01:20

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Sulfur is an essential element in biological systems, contributing to synthesizing key biomolecules, including amino acids such as cysteine and methionine, and cofactors such as coenzyme A and biotin. Microorganisms primarily assimilate sulfur as sulfate (SO₄²⁻) from the environment, which must undergo a series of biochemical transformations before it can be incorporated into cellular components. As sulfate is highly oxidized, it must undergo assimilatory sulfate reduction to become...
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Related Experiment Video

Updated: Jun 20, 2026

Deacetylation Assays to Unravel the Interplay between Sirtuins (SIRT2) and Specific Protein-substrates
14:32

Deacetylation Assays to Unravel the Interplay between Sirtuins (SIRT2) and Specific Protein-substrates

Published on: February 27, 2016

Function of SIRT1 in physiology.

Xing-Xing Kong1, Rui Wang, Xiao-Jun Liu

  • 1National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100005, China.

Biochemistry. Biokhimiia
|September 15, 2009
PubMed
Summary

Sirtuins are NAD+-dependent enzymes conserved in evolution. This review focuses on SIRT1, a key mammalian sirtuin involved in gene silencing, cell cycle, and energy homeostasis.

Related Experiment Videos

Last Updated: Jun 20, 2026

Deacetylation Assays to Unravel the Interplay between Sirtuins (SIRT2) and Specific Protein-substrates
14:32

Deacetylation Assays to Unravel the Interplay between Sirtuins (SIRT2) and Specific Protein-substrates

Published on: February 27, 2016

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Genetics

Background:

  • Sirtuins are a conserved family of NAD+-dependent enzymes.
  • They are homologous to the yeast Sir2 gene.
  • Mammalian sirtuins (SIRT1-7) regulate diverse cellular processes.

Purpose of the Study:

  • To review current data on SIRT1.
  • To discuss SIRT1's mode of action.
  • To explore SIRT1's biological role in cellular and organismal models.

Main Methods:

  • Literature review of recent studies on SIRT1.
  • Analysis of SIRT1's homology to Sir2.
  • Examination of SIRT1's involvement in cellular functions.

Main Results:

  • SIRT1 is a nuclear protein and the mammalian homolog of Sir2.
  • SIRT1 plays roles in gene silencing, cell cycle control, apoptosis, and energy homeostasis.
  • SIRT1 is a focus of extensive research due to its biological significance.

Conclusions:

  • SIRT1 is a crucial mammalian sirtuin with diverse regulatory functions.
  • Further research on SIRT1 is warranted to fully elucidate its biological roles.
  • Understanding SIRT1 mechanisms is vital for cellular and organismal health.