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Natriuretic peptides in septic patients
M Piechota1, M Barylski, S Hannam
1Department of Anaesthesiology and Intensive Care Unit, Medical University of Lodz, Poland, Hallera Sq 1, 90-647 Lodz, Poland. mariuszpiechota@poczta.onet.pl
Current Medicinal Chemistry
|September 15, 2009
Summary
Natriuretic peptides like atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) show potential as sepsis biomarkers. While elevated levels are reported in sepsis patients, further research is needed to clarify their diagnostic and therapeutic roles.
Area of Science:
- Biochemistry
- Cardiovascular Physiology
- Critical Care Medicine
Background:
- Natriuretic peptides (NPs) include ANP, BNP, CNP, DNP, and urodilatin, crucial in cardiovascular regulation.
- Sepsis is a life-threatening condition with increasing incidence, leading to multiorgan failure.
- Elevated ANP and BNP levels have been observed in sepsis patients, suggesting their potential as biomarkers.
Purpose of the Study:
- To explore the role of natriuretic peptides in sepsis diagnosis and treatment.
- To investigate the potential of ANP and pro-ANP as novel sepsis markers.
- To address the controversy surrounding NP levels in sepsis.
Main Methods:
- Review of existing literature on natriuretic peptides and sepsis.
- Analysis of studies reporting ANP and BNP levels in septic patients.
- Discussion of factors contributing to conflicting results, such as assay methodologies.
Main Results:
- Natriuretic peptides, particularly ANP and BNP, are frequently elevated in sepsis.
- Contradictory findings exist in the literature regarding NP levels in sepsis.
- Methodological differences in NP assays contribute to the observed discrepancies.
Conclusions:
- Natriuretic peptides show promise as diagnostic and/or therapeutic agents in sepsis.
- Further research is required to elucidate the underlying mechanisms and standardize measurement techniques.
- Standardized assays are crucial for reliable NP biomarker utilization in sepsis management.
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