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Related Concept Videos

Translational Regulation01:29

Translational Regulation

Translational regulation in prokaryotes ensures efficient protein synthesis by controlling ribosome access to mRNA. This regulation is mediated by secondary RNA structures, including translational riboswitches, RNA thermometers, and small RNAs (sRNAs), which respond to intracellular and environmental signals to modulate gene expression.Translational RiboswitchesRiboswitches in the leader region of mRNAs can regulate translation by altering the accessibility of the Shine-Dalgarno (SD) sequence,...
Pharmacogenomics: Identification of New Drug Targets01:29

Pharmacogenomics: Identification of New Drug Targets

Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
Ribosome Profiling02:24

Ribosome Profiling

Ribosome profiling or ribo-sequencing is a deep sequencing technique that produces a snapshot of active translation in a cell. It selectively sequences the mRNAs protected by ribosomes to get an insight into a cell’s translation landscape at any given point in time.
Applications of ribosome profiling
Ribosome profiling has many applications, including in vivo monitoring of translation inside a particular organ or tissue type and quantifying new protein synthesis levels.
The technique helps...
Genomics02:02

Genomics

Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
Improving Translational Accuracy02:07

Improving Translational Accuracy

Base complementarity between the three base pairs of mRNA codon and the tRNA anticodon is not a failsafe mechanism. Inaccuracies can range from a single mismatch to no correct base pairing at all. The free energy difference between the correct and nearly correct base pairs can be as small as 3 kcal/ mol. With complementarity being the only proofreading step, the estimated error frequency would be one wrong amino acid in every 100 amino acids incorporated. However, error frequencies observed in...
Improving Translational Accuracy02:07

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Base complementarity between the three base pairs of mRNA codon and the tRNA anticodon is not a failsafe mechanism. Inaccuracies can range from a single mismatch to no correct base pairing at all. The free energy difference between the correct and nearly correct base pairs can be as small as 3 kcal/ mol. With complementarity being the only proofreading step, the estimated error frequency would be one wrong amino acid in every 100 amino acids incorporated. However, error frequencies observed in...

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Planning for translational research in genomics.

Naomi Hawkins1, Jantina de Vries, Paula Boddington

  • 1The Ethox Centre, Department of Public Health, University of Oxford, Old Road Campus, Headington, Oxford OX3 7LF, UK. naomi.hawkins@ethox.ox.ac.uk.

Genome Medicine
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PubMed
Summary

Genomic research translation into clinical practice requires early planning for collaboration, revenue sharing, and sample collection. Proactive management optimizes long-term health benefits from genomic discoveries.

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Area of Science:

  • Genomics
  • Translational Research
  • Medical Progress

Background:

  • Translating research into clinical practice is vital for medical advancement.
  • Genomic research, even in early stages, raises questions about its utility in treatment and public health.
  • Early consideration of translational issues enhances future clinical application of genomic findings.

Purpose of the Study:

  • To highlight the importance of early planning in genomic research translation.
  • To discuss key factors influencing successful translation of genomic research findings.
  • To optimize the long-term benefits of genomic research for public health.

Main Methods:

  • Discussion of key areas in translational research planning.
  • Focus on collaboration agreements.
  • Examination of revenue distribution and sample collection strategies.

Main Results:

  • Simple planning steps can significantly improve the pathway for genomic research translation.
  • Awareness of translational issues early on is crucial.
  • Proactive management enhances the delivery of research to the clinic.

Conclusions:

  • Effective management of collaboration, revenue, and sample collection is essential for successful genomic translational research.
  • Strategic planning in the initial stages maximizes the long-term health benefits of genomic discoveries.
  • Addressing translational aspects early ensures genomic research contributes effectively to clinical practice and public health.