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Related Concept Videos

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Related Experiment Video

Updated: Jun 20, 2026

Method of Studying Palatal Fusion using Static Organ Culture
04:58

Method of Studying Palatal Fusion using Static Organ Culture

Published on: September 19, 2015

Cleft lip and palate.

Peter A Mossey1, Julian Little, Ron G Munger

  • 1Department of Dental and Oral Health, University of Dundee, Dental Hospital and School, Dundee, UK. p.a.mossey@dundee.ac.uk

Lancet (London, England)
|September 15, 2009
PubMed
Summary

Cleft lip and palate are common birth defects affecting 1.7 in 1000 babies, causing lifelong health and social challenges. Understanding genetic and environmental causes is key to preventing these complex oral and facial disorders.

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Isolation and Time-Lapse Imaging of Primary Mouse Embryonic Palatal Mesenchyme Cells to Analyze Collective Movement Attributes
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Published on: February 13, 2021

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Last Updated: Jun 20, 2026

Method of Studying Palatal Fusion using Static Organ Culture
04:58

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Published on: September 19, 2015

Isolation and Time-Lapse Imaging of Primary Mouse Embryonic Palatal Mesenchyme Cells to Analyze Collective Movement Attributes
07:13

Isolation and Time-Lapse Imaging of Primary Mouse Embryonic Palatal Mesenchyme Cells to Analyze Collective Movement Attributes

Published on: February 13, 2021

Area of Science:

  • Craniofacial anomalies
  • Developmental biology
  • Public health

Background:

  • Cleft lip and palate (CLP) are common congenital anomalies affecting the lips and oral cavity.
  • These conditions present significant challenges impacting speech, hearing, appearance, and psychological well-being.
  • Individuals with CLP often require lifelong multidisciplinary care, facing increased morbidity and mortality.

Purpose of the Study:

  • To provide a comprehensive overview of cleft lip and palate disorders.
  • To discuss the embryological origins, epidemiology, and risk factors.
  • To highlight the importance of understanding causes for effective prevention strategies.

Main Methods:

  • Review of embryological development processes related to CLP.
  • Epidemiological analysis of CLP incidence and variations.
  • Examination of known environmental and genetic risk factors and their interactions.

Main Results:

  • CLP affects approximately 1.7 per 1000 liveborn infants, with notable ethnic and geographic variations.
  • Identified environmental and genetic factors contribute to CLP development.
  • Despite increased access to care, quality remains variable globally.

Conclusions:

  • Elucidating the causes of CLP is crucial for developing effective prevention strategies.
  • Multidisciplinary care is essential for managing the long-term health and social integration of affected individuals.
  • Technological advancements and international collaboration are vital for progress in understanding and managing CLP.