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"Paradoxical" growth hormone secretion in acromegaly: an avian model?
1Department of Physiology, University of Alberta, Edmonton, Canada.
The Journal of Experimental Zoology. Supplement : Published Under Auspices of the American Society of Zoologists and the Division of Comparative Physiology and Biochemistry
|January 1, 1990
Abstract:
Acromegaly is a pathological human condition resulting from an excess of growth hormone (GH) secretion in adults. The regulation of GH secretion in acromegalics is characterised by "paradoxical" GH responses to dynamic tests of pituitary GH function. Many of these "paradoxical" responses appear to be normal, physiological GH responses in aves. Comparative studies on the control of GH secretion in immature birds may therefore provide an experimental model for testing the effects of therapeutic agents of GH secretion.