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Lack of association between hepatitis C infection and chronic kidney disease

Sumeet K Asrani1, Paula Buchanan, Brett Pinsky

  • 1Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA.

Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association
|September 15, 2009
PubMed

Insights

This study found no link between hepatitis C virus (HCV) infection and the development of chronic kidney disease (CKD). These findings are important for understanding HCV

Area of Science:

  • Nephrology
  • Hepatology
  • Epidemiology

Background:

  • Chronic kidney disease (CKD) is known to worsen outcomes for patients with hepatitis C virus (HCV) infection.
  • The independent impact of HCV on CKD development requires further investigation.

Purpose of the Study:

  • To determine if HCV status independently affects the risk of developing CKD.
  • To analyze the association between HCV and CKD prevalence and progression.

Main Methods:

  • A cohort study of 167,569 patients from a national health care claims database (2003-2006).
  • Multivariable logistic regression analyses were used to assess the effect of HCV status on CKD.
  • CKD was defined as an estimated glomerular filtration rate <60 mL/min/1.73 m(2).

Main Results:

  • No significant difference in baseline CKD prevalence between patients with and without HCV (5.3% vs 5.1%).
  • No difference in CKD progression among patients with preserved renal function at baseline (3.8% vs 3.5%).
  • HCV status was not associated with CKD progression after adjusting for demographics and comorbidities (OR, 0.92; 95% CI, 0.79-1.08).

Conclusions:

  • No association was found between HCV infection and the risk of developing CKD.
  • These findings suggest HCV does not independently impact renal function decline.
  • Data are relevant for counseling HCV patients on kidney health.
Abstract

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