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Fetal intracerebral hemorrhage in familial thrombophilia

Malvina Crespin1, Martine Alhenc-Gelas, Gilles Grangé

  • 1Assistance-Publique-Hôpitaux de Paris, Paris, France.

Pediatric Neurology
|September 15, 2009
PubMed

We describe a fetal intracerebral hemorrhage associated with familial thrombophilia. Intraventricular and intraparenchymal hemorrhage of the left cerebral hemisphere was diagnosed at 22 weeks of gestation. Neuropathologic examination demonstrated a large germinal zone hemorrhage and ischemic changes secondary to bleeding. The fetus manifested a heterozygous Leiden mutation of the factor V gene, and a heterozygous F76L mutation of the protein C gene. The literature indicates that the coexistence of genetic risk factors of thrombophilia and fetal intracerebral hemorrhage is rare, except in the context of pregnancy-related complications. The utility of laboratory screening is discussed.

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