[Immunostimulating effect of D2 dopamine receptor agonist quinpirole]

Immunostimulating activity of specific postsynaptic D2 receptor agonist quinpirole (Ly 171555) was studied in CBA mice. The drug was administered intraperitoneally in a dose of 1 mg/kg 30 min before the immunization with SRBC (5 x 10(8)). Considerable stimulation of rosette- and plaque-forming cell number was observed at the early stage (3-d day) and at more late stage of the immune response (5-th day). The increase of rosette- and plaque-forming cell number was provided by IgM-reaction enhancement.