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Drug Dosing: Geriatric Patients

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Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...

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Dementia l: Introduction

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Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

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Dementia

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Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
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Updated: Jun 20, 2026

Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach

Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach

Published on: February 14, 2014

[Depression and frontal dysfunction: risks for the elderly?].

P Thomas¹, C Hazif Thomas, R Billon

¹Service universitaire de psychogériatrie, centre mémoire de ressources et de recherches, centre hospitalier Esquirol, 87025 Limoges, France. philippe.thomas@ch-esquirol-limoges.fr

|September 15, 2009

Summary

This summary is machine-generated.

Geriatric depression is linked to impaired executive functioning, increasing fall and malnutrition risks in older adults. Addressing executive dysfunction is key for effective late-life depression treatments.

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Last Updated: Jun 20, 2026

Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach

Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach

Published on: February 14, 2014

Area of Science:

Geriatric Psychiatry
Neuropsychology
Neurology

Context:

Frontal lobe syndromes, characterized by executive dysfunction, are increasingly recognized in geriatric populations.
Executive dysfunction may underlie geriatric and vascular depression, potentially stemming from frontostriatal circuit impairment.
This study investigates the link between executive impairment and depressive symptoms in a psychogeriatric cohort.

Purpose:

To examine the relationship between executive impairment and the course of depressive symptoms in elderly individuals with dementia or depression.
To assess the consequences of these pathologies on disabilities in aged persons.
To determine if depression combined with executive dysfunction increases risks of falls and malnutrition.

Summary:

A study of 321 psychogeriatric outpatients found that depression with executive dysfunction syndrome significantly increases the loss of autonomy, risk of falls, and malnutrition, particularly in those with cognitive impairment.
Multivariate regression analysis confirmed an increased risk of falls in patients with depression-executive dysfunction syndrome.
Depression exacerbates behavioral disorders, social/familial relationship issues, and difficulties with daily life activities in demented patients, precipitating falls and malnutrition.

Impact:

Geriatric depression is strongly associated with impaired executive functioning, impacting daily activities and compensatory strategies.
Executive dysfunction in depressed older adults can lead to increased dependency and poorer outcomes.
Identifying specific executive deficits in depressed elderly patients can guide the development of targeted interventions for geriatric depression and improve patient outcomes.