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Related Concept Videos

Notch Signaling Pathway03:14

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
Notch Signaling Pathway03:14

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
Mechanisms of Membrane Domain Formation00:59

Mechanisms of Membrane Domain Formation

Different physical properties of lipids and proteins allow them to localize and form distinct islands or domains in the membrane. Some membrane domains are formed due to protein-protein interactions, whereas others are formed due to the presence of specific lipids such as sphingolipids and sterols—for example, large proteins, such as bacteriorhodopsin, aggregate and create distinct domains.
Another mechanism for membrane domain formation involves membrane proteins interacting with cytoskeletal...
Natural Selection and Adaptation01:15

Natural Selection and Adaptation

Natural selection, a fundamental concept in evolutionary biology, is the mechanism by which evolution is driven, favoring organisms that are best adapted to their environments. This process enhances their chances of survival and reproduction. Adaptation, a key outcome of this process, involves genetic modifications that optimize an organism's functionality under specific environmental challenges, such as extreme cold or thinner air at high altitudes.
Beyond physical adaptations, psychological...
What is Natural Selection?01:32

What is Natural Selection?

Natural selection is an evolutionary process in which individuals with survival-promoting traits reproduce at higher rates. These favorable traits become more common within a population or species. Naturally selected traits initially arise via random genetic mutations. In order for selection to occur, there must be variation within a population, the trait controlling the variation must be heritable, and there must be an evolutionary advantage for variation in the trait.The Theory of Natural...
Mechanism of Lamellipodia Formation01:31

Mechanism of Lamellipodia Formation

Cells migrating in response to external stimuli form lamellipodia, which are thin membrane protrusions supported by a mesh of linked, branched, or unbranched actin filaments. These actin filaments interact with myosin motor proteins, creating the dynamic actomyosin complex within the cytoskeleton. Contractility, or the ability to generate contractile stress, is inherent to the actomyosin complex. It helps cells detect the stiffness of the surrounding ECM and exert contractile force for...

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Related Experiment Video

Updated: Jun 20, 2026

Stimulation of Notch Signaling in Mouse Osteoclast Precursors
08:01

Stimulation of Notch Signaling in Mouse Osteoclast Precursors

Published on: February 28, 2017

Notch: a new player in MS mechanisms.

Maciej Juryńczyk1, Krzysztof Selmaj

  • 1Department of Neurology, Medical University of Lodz, Kopcińskiego 22, Poland. maciej.jurynczyk@umed.lodz.pl

Journal of Neuroimmunology
|September 15, 2009
PubMed
Summary

Notch signaling regulates immune and glial cells crucial for multiple sclerosis (MS). Modulating this pathway in experimental autoimmune encephalomyelitis (EAE) reduces disease severity, suggesting therapeutic potential for MS.

Area of Science:

  • Neuroimmunology
  • Cellular signaling pathways

Background:

  • The Notch signaling pathway is vital for cell differentiation and tissue development.
  • Recent research highlights Notch's role in immune cell function, oligodendrocyte maturation, and microglial activation.
  • Notch pathway components are upregulated in multiple sclerosis (MS) lesions and its animal model, experimental autoimmune encephalomyelitis (EAE).

Purpose of the Study:

  • To review Notch signaling's impact on immune and glial cells in the context of MS.
  • To analyze the involvement of the Notch pathway in MS and EAE pathogenesis.
  • To explore the therapeutic potential of targeting Notch signaling for MS treatment.

Main Methods:

  • Review of recent scientific literature on Notch signaling in neuroinflammation and demyelinating diseases.

More Related Videos

Real-time Bioluminescence Imaging of Notch Signaling Dynamics during Murine Neurogenesis
10:25

Real-time Bioluminescence Imaging of Notch Signaling Dynamics during Murine Neurogenesis

Published on: December 12, 2019

Related Experiment Videos

Last Updated: Jun 20, 2026

Stimulation of Notch Signaling in Mouse Osteoclast Precursors
08:01

Stimulation of Notch Signaling in Mouse Osteoclast Precursors

Published on: February 28, 2017

Real-time Bioluminescence Imaging of Notch Signaling Dynamics during Murine Neurogenesis
10:25

Real-time Bioluminescence Imaging of Notch Signaling Dynamics during Murine Neurogenesis

Published on: December 12, 2019

  • Analysis of data implicating Notch pathway components in the development and progression of MS and EAE.
  • Discussion of experimental findings from EAE models regarding Notch pathway modulation.

    • Main Results:

    • Notch signaling influences the differentiation and function of T cells, oligodendrocytes, macrophages, and microglia.
    • In vivo modulation of Notch signaling in EAE impacts myelin-reactive T cell responses.
    • Targeting Notch signaling in EAE enhances tissue repair and ameliorates clinical disease severity.

    Conclusions:

    • The Notch pathway plays a significant role in the immune and glial cell dysregulation observed in MS.
    • Evidence from EAE models suggests that manipulating Notch signaling can be a viable therapeutic strategy for MS.
    • Further investigation into Notch pathway modulation holds promise for novel MS therapies.