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Accurate assessment of intragenic recombination frequency within the Duchenne muscular dystrophy gene
S Abbs1, R G Roberts, C G Mathew
1Paediatric Research Unit, United Medical School Guy's Hospital, London, United Kingdom.
Genomics
|August 1, 1990
Abstract:
Polymorphic loci that lie at the two extremities of the Duchenne/Becker muscular dystrophy (DMD/BMD) gene have been used to estimate intragenic recombination rates. Multipoint linkage analysis of the CEPH panel of families suggests a total intragenic recombination frequency of nearly 0.12 (confidence intervals 0.041-0.226) over the genomic length of approximately 2 Mb.