Related Experiment Video

Updated: Jun 20, 2026

Microtransplantation of Synaptic Membranes to Reactivate Human Synaptic Receptors for Functional Studies
10:08

Microtransplantation of Synaptic Membranes to Reactivate Human Synaptic Receptors for Functional Studies

Published on: July 20, 2022

Therapeutic promise and principles: metabotropic glutamate receptors

Kenneth Maiese1, Zhao Zhong Chong, Yan Chen Shang

  • 1Division of Cellular and Molecular Cerebral Ischemia, Wayne State University School of Medicine, Detroit, Michigan 48201, USA. kmaiese@med.wayne.edu

Oxidative Medicine and Cellular Longevity
|September 15, 2009
PubMed

Insights

Oxidative stress contributes to many diseases. Targeting metabotropic glutamate receptors (mGluRs) and their signaling pathways offers potential therapeutic strategies for conditions like diabetes and Alzheimer's disease.

Area of Science:

  • Neuroscience
  • Cell Biology
  • Pharmacology

Background:

  • Oxidative stress is implicated in the etiology and progression of various diseases, including diabetes, Alzheimer's disease, Parkinson's disease, and immune dysfunction.
  • Novel therapeutic strategies targeting signal transduction pathways are needed to mitigate the toxic effects of oxidative stress.

Purpose of the Study:

  • To explore the potential clinical translation of metabotropic glutamate receptors (mGluRs) as therapeutic targets.
  • To highlight the role of novel signal transduction pathways within the metabotropic glutamate system for clinical utility.

Main Methods:

  • Review of existing literature on oxidative stress, mGluRs, and related signaling pathways.
  • Discussion of the complex role of mGluRs in cellular function and disease pathology.

Main Results:

  • Metabotropic glutamate receptors (mGluRs) show promise in limiting or preventing apoptotic cell injury.
  • mGluRs influence cellular development and function, suggesting broad therapeutic potential.
  • The role of mGluRs is complex and requires specific modulation for different disease entities to ensure efficacy and minimize adverse effects.

Conclusions:

  • Metabotropic glutamate receptors (mGluRs) represent a promising therapeutic target for a range of disorders associated with oxidative stress.
  • Understanding and modulating novel signal transduction pathways in the metabotropic glutamate system is crucial for successful clinical translation.
Keywords:
AktAlzheimer's diseaseHuntington's diseaseWntamyotrophic lateral sclerosisapoptosiserythropoietinforkheadmetabotropicoxidative stressβ-catenin

More Related Videos

Visualizing the Conformational Dynamics of Membrane Receptors Using Single-Molecule FRET10:59

Visualizing the Conformational Dynamics of Membrane Receptors Using Single-Molecule FRET

Published on: August 17, 2022

HSV-Mediated Transgene Expression of Chimeric Constructs to Study Behavioral Function of GPCR Heteromers in Mice07:30

HSV-Mediated Transgene Expression of Chimeric Constructs to Study Behavioral Function of GPCR Heteromers in Mice

Published on: July 9, 2016

Related Concept Videos

Ligand-Gated Ion Channel Receptor: Gating Mechanism01:30

Ligand-Gated Ion Channel Receptor: Gating Mechanism

Ligand-gated ion channels are transmembrane proteins that play a vital role in intercellular communication and functions of the nervous system. They allow the influx of ions across the membrane once the neurotransmitter binds, allowing the subsequent transmission of electrical excitation across the neurons. Other ligand-gated ion channels, like the γ-aminobutyric acid (GABA) receptor, permit anions like chloride into the cells on the binding of the GABA molecule. Their entry into the cell...
Ligand-gated Ion Channels01:19

Ligand-gated Ion Channels

Ligand-gated ion channels are transmembrane proteins with a channel for ions to pass through and a binding site for a ligand. The channel opens only when a ligand attaches to the binding site.
Three Subfamilies of Ligand-gated Ion Channels
Ligand-gated ion channels fall into three subfamilies. The 'Cys-loop' includes the nicotinic acetylcholine receptors, γ-aminobutyric acid (GABA), glycine, and 5-hydroxytryptamine receptors. The second one is the 'Pore-loop' channels that include the...
Antiepileptic Drugs: Glutamate Antagonists01:14

Antiepileptic Drugs: Glutamate Antagonists

Glutamate is a fundamental neurotransmitter in the central nervous system, playing a vital role in neuronal communication and various cognitive processes. Glutamate stands as the principal excitatory neurotransmitter in the brain. Its presence is crucial for the communication between neurons, underpinning essential processes such as synaptic transmission, neuronal excitability, and plasticity. These functions are vital for higher-order cognitive processes, including learning and memory. The...
G Protein-coupled Receptors01:15

G Protein-coupled Receptors

G Protein-Coupled Receptors or GPCRs are membrane-bound receptors that transiently associate with heterotrimeric G proteins and induce an appropriate response to sensory stimuli such as light, odors, hormones, cytokines, or neurotransmitters.
GPCRs are also called heptahelical, 7TM, or serpentine receptors, and consist of seven (H1-H7) transmembrane alpha-helices that span the bilayer to form a cylindrical core. The transmembrane helices are connected by three extracellular loops and three...
G Protein-coupled Receptors01:15

G Protein-coupled Receptors

G Protein-Coupled Receptors or GPCRs are membrane-bound receptors that transiently associate with heterotrimeric G proteins and induce an appropriate response to sensory stimuli such as light, odors, hormones, cytokines, or neurotransmitters.
GPCRs are also called heptahelical, 7TM, or serpentine receptors, and consist of seven (H1-H7) transmembrane alpha-helices that span the bilayer to form a cylindrical core. The transmembrane helices are connected by three extracellular loops and three...
Transducer Mechanism: G Protein–Coupled Receptors01:30

Transducer Mechanism: G Protein–Coupled Receptors

G Protein–Coupled Receptors (GPCRs) are membrane-bound receptors that transiently associate with heterotrimeric G proteins and induce an appropriate response to various stimuli. GPCRs regulate critical physiological pathways and are excellent drug targets for treating diseases such as diabetes, cancer, obesity, depression, or Alzheimer's. Nearly 35% of approved drugs implement their therapeutic effects by selectively interacting with specific GPCRs.
GPCRs are also called heptahelical, 7TM, or...