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Related Experiment Video

Updated: Jun 20, 2026

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells

Published on: May 30, 2025

Can Sir(2) regulate cancer?

Pratibha V Nerurkar¹, Vivek R Nerurkar

¹Laboratory of Metabolic Disorders and Alternative Medicine, Dept. of Molecular Biosciences and Bioengineering (MBBE), CTAHR, , University of Hawaii, Honolulu.

Cellscience

|September 28, 2011

Summary

Sirtuin activators show promise for metabolic disorders and aging. However, inhibiting sirtuin 1 (SIRT1) may benefit cancer treatment and fragile X syndrome by modulating cell death and gene expression.

Area of Science:

Biochemistry
Molecular Biology
Genetics

Background:

Sirtuin activators, like resveratrol, are investigated for metabolic health and anti-aging effects.
Sirtuin 1 (SIRT1) plays a dual role, with potential benefits in aging and metabolic disorders.
Recent research highlights negative regulation of SIRT1.

Purpose of the Study:

To explore the dual role of sirtuin 1 (SIRT1) in both promoting health and disease.
To investigate the therapeutic potential of modulating SIRT1 activity.

Main Methods:

Review of recent studies on sirtuin activators and inhibitors.
Analysis of SIRT1's interaction with deleted in breast cancer 1 (DBC1).
Examination of SIRT1's role in p53-induced apoptosis and radiation sensitization in cancer cells.

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Published on: June 4, 2012

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Last Updated: Jun 20, 2026

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells

Published on: May 30, 2025

Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis

Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis

Published on: March 30, 2019

DNA Vector-based RNA Interference to Study Gene Function in Cancer

DNA Vector-based RNA Interference to Study Gene Function in Cancer

Published on: June 4, 2012

Main Results:

Sirtuin activators are beneficial for metabolic disorders and aging.
Targeted silencing of SIRT1 by DBC1 promotes cancer cell apoptosis and radiation sensitivity.
Negative SIRT1 regulation alleviates gene repression in fragile X mental retardation syndrome.

Conclusions:

Modulating sirtuin 1 (SIRT1) activity is a critical regulatory point for disease pathogenesis.
Targeted activation or inhibition of SIRT1 offers potential therapeutic strategies for diverse conditions.