Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Substance Use Disorders Affecting Sleep

Substance Use Disorders Affecting Sleep

Substance use disorders involve a pattern of using drugs more extensively than intended and continuing use despite harmful consequences. This includes legal substances like alcohol and nicotine, as well as illegal drugs. These disorders often involve both physical and psychological dependence, reflecting compulsive use of substances that significantly alter thoughts, feelings, and behaviors, contributing to a major public health issue.
Understanding the concepts of physical dependence,...

Insufficient Sleep and Sleep Deprivation

Insufficient Sleep and Sleep Deprivation

Insufficient sleep refers to not getting the recommended amount of sleep for optimal functioning, even if it's just slightly less than needed. Sleep insufficiency may occur due to lifestyle choices, such as staying up late for social events or work, resulting in routinely getting less sleep than required. For example, consistently sleeping 6 hours when the body needs 7-9 hours can lead to cumulative effects on health and well-being.
Sleep deprivation is a more severe form of sleep loss...

Negative and Cognitive Symptoms of Schizophrenia

Negative and Cognitive Symptoms of Schizophrenia

Negative symptoms of schizophrenia indicate a reduction or absence of typical behaviors and emotional responses found in healthy individuals, while positive symptoms reflect an excess or distortion of normal functioning.
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...

Biological Causes of Schizophrenia

Biological Causes of Schizophrenia

Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin studies.

Understanding Sleep

Understanding Sleep

Sleep, an essential biological state, involves significant reductions in physical activity, sensory awareness, and interaction with the environment. This complex physiological process is primarily regulated by specific brain regions, notably the hypothalamus and pons, which govern the sleep-wake cycle or circadian rhythm.
The circadian rhythm, a nearly 24-hour cycle, is deeply influenced by environmental light cues. Light exposure directly affects the hypothalamus, which in turn regulates...

REM Sleep Behavior Disorder

REM Sleep Behavior Disorder

REM Sleep Behavior Disorder (RBD) is a sleep disorder characterized by the absence of muscle paralysis that normally occurs during the REM phase of sleep. This absence allows individuals to physically act out their dreams, which are often vivid and disturbing. Common behaviors exhibited during episodes include kicking, punching, and yelling. These actions can be dangerous, potentially leading to injuries for the person with RBD or their bed partner.
RBD is significantly associated with...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Targeted dream incubation at sleep onset can influence later dream content in REM sleep: a pilot study.

Frontiers in sleep·2026

Same author

Brain Health from Sleep EEG: A Multicohort, Deep Learning Biomarker for Cognition, Disease, and Mortality.

NEJM AI·2026

Same author

Sleep and wake markers of thalamocortical functioning in early-course psychosis and first-degree relatives.

Schizophrenia (Heidelberg, Germany)·2026

Same author

Intact sleep-dependent memory consolidation of auditory statistical learning among young adults with ADHD.

Research in developmental disabilities·2026

Same author

Recovery sleep after total sleep deprivation preserves neutral and enhances emotional declarative memory.

Sleep advances : a journal of the Sleep Research Society·2026

Same author

Auditory-evoked changes in slow oscillations and spindles correlate with memory consolidation in children with epilepsy and controls.

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology·2025

Search research articles

Related Experiment Video

Updated: Jun 20, 2026

Measuring Neural Mechanisms Underlying Sleep-Dependent Memory Consolidation During Naps in Early Childhood

Measuring Neural Mechanisms Underlying Sleep-Dependent Memory Consolidation During Naps in Early Childhood

Published on: October 2, 2019

Does abnormal sleep impair memory consolidation in schizophrenia?

Dara S Manoach¹, Robert Stickgold

¹Department of Psychiatry, Massachusetts General Hospital Charlestown, MA 02129 , USA. dara@nmr.mgh.harvard.edu

Frontiers in Human Neuroscience

|September 15, 2009

Summary

Schizophrenia patients exhibit disturbed sleep, which impairs memory consolidation and attention. Addressing these sleep deficits may improve cognitive function and outcomes in schizophrenia.

Keywords:

cognition memory consolidation motor skill procedural learning schizophrenia sleep sleep spindles slow wave sleep

More Related Videos

A High-performance Liquid Chromatography Measurement of Kynurenine and Kynurenic Acid: Relating Biochemistry to Cognition and Sleep in Rats

A High-performance Liquid Chromatography Measurement of Kynurenine and Kynurenic Acid: Relating Biochemistry to Cognition and Sleep in Rats

Published on: August 19, 2018

Eye Tracking, Cortisol, and a Sleep vs. Wake Consolidation Delay: Combining Methods to Uncover an Interactive Effect of Sleep and Cortisol on Memory

Eye Tracking, Cortisol, and a Sleep vs. Wake Consolidation Delay: Combining Methods to Uncover an Interactive Effect of Sleep and Cortisol on Memory

Published on: June 18, 2014

Related Experiment Videos

Last Updated: Jun 20, 2026

Measuring Neural Mechanisms Underlying Sleep-Dependent Memory Consolidation During Naps in Early Childhood

Measuring Neural Mechanisms Underlying Sleep-Dependent Memory Consolidation During Naps in Early Childhood

Published on: October 2, 2019

A High-performance Liquid Chromatography Measurement of Kynurenine and Kynurenic Acid: Relating Biochemistry to Cognition and Sleep in Rats

A High-performance Liquid Chromatography Measurement of Kynurenine and Kynurenic Acid: Relating Biochemistry to Cognition and Sleep in Rats

Published on: August 19, 2018

Eye Tracking, Cortisol, and a Sleep vs. Wake Consolidation Delay: Combining Methods to Uncover an Interactive Effect of Sleep and Cortisol on Memory

Eye Tracking, Cortisol, and a Sleep vs. Wake Consolidation Delay: Combining Methods to Uncover an Interactive Effect of Sleep and Cortisol on Memory

Published on: June 18, 2014

Area of Science:

Neuroscience
Psychiatry
Sleep Medicine

Background:

Disturbed sleep is a hallmark of schizophrenia, yet its impact on cognitive deficits is understudied.
Cognitive impairment is a primary concern in schizophrenia, affecting learning, memory, and daily functioning.
Memory consolidation, crucial for learning, predominantly occurs during sleep.

Purpose of the Study:

To review the relationship between abnormal sleep and cognitive deficits in schizophrenia.
To explore sleep-dependent memory consolidation in healthy individuals and its impairment in schizophrenia.
To discuss the implications of impaired sleep-dependent memory consolidation for schizophrenia treatment.

Main Methods:

Literature review of studies on sleep disturbances in schizophrenia.
Examination of research on sleep-dependent memory consolidation in healthy populations.
Analysis of recent findings on impaired sleep-dependent memory consolidation in schizophrenia patients.

Main Results:

Schizophrenia is characterized by abnormal sleep patterns that disrupt attention.
Sleep-dependent memory consolidation is significantly impaired in individuals with schizophrenia.
These sleep-related impairments contribute to difficulties in task automation and cognitive processing.

Conclusions:

Abnormal sleep in schizophrenia disrupts cognitive functions, including attention and memory consolidation.
Impaired sleep-dependent memory consolidation may be a key factor contributing to overall cognitive deficits in schizophrenia.
Targeting sleep disturbances presents a potential therapeutic strategy for improving cognitive outcomes in schizophrenia.