Related Experiment Videos
The evaluation of relationship between group A streptococcal infection with tic disorders in children
Soroor Arman1, Javad Golmirzaei, Alireza E Naeini
1Department of Child and Adolescent Psychiatry, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Insights
Group A beta-hemolytic streptococcus (GABHS) infection shows a correlation with childhood tic disorders. Further research is needed to determine if GABHS infection causes tic disorders.
Area of Science:
- Pediatric Psychiatry
- Infectious Diseases
- Neuroscience
Background:
- Group A beta-hemolytic streptococcus (GABHS) infections are common in children.
- The potential link between GABHS and neurological disorders, such as tic disorders, is an area of ongoing research.
- Understanding this relationship may inform diagnostic and treatment approaches for childhood tics.
Purpose of the Study:
- To investigate the association between GABHS infection and the presence of tic disorders in children.
- To compare the prevalence of GABHS infection markers in children with and without tic disorders.
Main Methods:
- A case-control study involving 36 children with tic disorders and 36 controls (aged 5-15).
- Clinical interviews using DSM IV-TR criteria and laboratory tests including throat culture, rapid antigen detection test (RADT), and anti-streptolysin O (ASO) titers were performed.
- The Yale Global Tics Severity Scale (YGTSS) was used to assess tic severity.
Main Results:
- A statistically significant difference (p<0.05) in GABHS infection markers was observed between the tic group (44.4%) and the control group (25%).
- The rapid antigen detection test (RADT) demonstrated 100% specificity.
- No significant correlation was found between ASO titers and YGTSS scores.
Conclusions:
- The study found a correlation between GABHS infection and tic disorders in children.
- While a link is suggested, the findings do not establish a causal relationship between GABHS infection and the development of tic disorders.
Objective:
To evaluate the relationship between group A beta hemolytic streptococcus infection (GABHS) and tic disorders in children.
Methods:
This is a case-control study that was conducted in Child and Adolescent Psychiatric Clinic, Isfahan, Iran, between May 2008 and February 2009. Thirty-six children (aged 5-15) with tic and 36 children without tic and obsessive-compulsive disorder (OCD) were investigated for clinical and laboratory signs of GABHS. The tools utilized in this research were clinical interview according to the DSM IV-TR and laboratory tests (throat culture, rapid antigen detection test [RADT], anti streptolysin O [ASO] and yale global tics severity scale [YGTSS]). The control group was of the same gender and age as the tic group who had come to the clinic for other illnesses and was in need of blood test. None of the subjects in the case and control groups had a clinical history of GABHS infection.
Results:
The relationship between tic disorder and GABHS infection (if any of these laboratory tests takes place: throat culture, RADT, ASO > or = 250) in the tic group was 16 (44.4%) and in the control group was 9 (25%), there were significant differences (p<0.05). No significant correlation was found between ASO titer and YGTSS scores. The specificity of RADT was 100%.
Conclusion:
The result showed correlation between GABHS infection and tic disorder, but it does not mean that GABHS infection caused tic disorder.
Related Concept Videos
01:30Tonsillitis I: Introduction
Etiology
Three primary contributing factors have been identified.
01:22Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies
01:28Toxoplasmosis