Related Experiment Video

Updated: Jun 20, 2026

Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models
08:57

Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models

Published on: May 17, 2024

[Malignant masquerade syndromes]

J Heissigerová1, E Ríhová, P Svozílková

  • 1Centrum pro diagnostiku a lécbu uveitid, Ocní klinika VFN a 1. LF UK, Praha. j.heissigerova@yahoo.co.uk

Ceska a Slovenska Oftalmologie : Casopis Ceske Oftalmologicke Spolecnosti a Slovenske Oftalmologicke Spolecnosti
|September 16, 2009
PubMed
Abstract

Insights

Malignant masquerade syndromes, often misdiagnosed as idiopathic uveitis, require prompt diagnosis. Analysis of intraocular fluids is key for identifying these serious conditions and improving patient outcomes.

Area of Science:

  • Ophthalmology
  • Oncology
  • Immunology

Context:

  • Masquerade syndromes present a diagnostic challenge in ophthalmology, mimicking chronic uveitis.
  • Intraocular tumors and lymphomas can present as masquerade syndromes, necessitating careful evaluation.
  • Idiopathic uveitis is a common initial diagnosis for masquerade syndromes, delaying appropriate treatment.

Purpose:

  • To evaluate the diagnostic and treatment experience with malignant masquerade syndromes.
  • To identify the most frequent causes and effective diagnostic methods for malignant masquerade syndromes.

Summary:

  • A retrospective study analyzed 46 patients with malignant masquerade syndromes, a subset of 89 masquerade syndromes identified from 1233 uveitis cases.
  • Intraocular non-Hodgkin lymphoma was the most common cause (26 patients).
  • Analysis of intraocular fluids proved to be the most valuable diagnostic procedure.

Impact:

  • Highlights the importance of considering malignant masquerade syndromes in corticosteroid-resistant chronic uveitis.
  • Emphasizes that timely diagnosis and treatment can improve prognosis and potentially control life-threatening conditions.

Related Concept Videos

Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Cirrhosis I: Introduction01:23

Cirrhosis I: Introduction

Cirrhosis is a chronic, irreversible liver disease characterized by the widespread replacement of healthy liver tissue with fibrotic scar tissue and the formation of regenerative nodules.Etiology of cirrhosisCirrhosis results from sustained liver injury that triggers progressive fibrosis and structural remodeling. The underlying causes are diverse, encompassing common and less frequent clinical conditions. Regardless of the origin, all causes lead to chronic inflammation, hepatocyte loss, and...
Positive Symptoms of Schizophrenia: Hallucinations and Delusions01:30

Positive Symptoms of Schizophrenia: Hallucinations and Delusions

Schizophrenia is a complex mental health disorder that can manifest with various positive symptoms, including thought, movement, and behavior disorders. These symptoms significantly disrupt cognitive and motor functions, leading to profound effects on an individual's ability to engage with the world.
Thought Disorders
Disorganized and unusual thought processes mark thought disorders in schizophrenia. One key feature is disorganized speech, where an individual's conversation includes loosely...
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...
Dark Triad and Person Perception01:29

Dark Triad and Person Perception

Person perception is influenced by both external behaviors and the observer’s internal characteristics, including personality traits. Individuals with dark personality traits, comprising psychopathy, Machiavellianism, and narcissism — collectively known as the dark triad – exhibit manipulative and exploitative tendencies in social contexts. These traits affect how they perceive others and how they are perceived.The Role of Dark Personality Traits in Person PerceptionBlack et al. (2014) explored...
Masking and Demasking Agents01:19

Masking and Demasking Agents

EDTA titrations may necessitate masking and demasking agents to temporarily protect a particular metal ion in a mixture from the EDTA reaction. These agents facilitate the sequential analysis of the metal ions by forming stable complexes with some—but not all—metal ions during certain steps.
There are many masking agents, such as cyanide, fluoride, triethanolamine, thiourea, and 2,3-bis(sulfanyl)propan-1-ol (formerly 2,3-dimercapto-1-propanol), with the masking agent chosen based on the metal...