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A review on mouth dissolving films
Meenu Dahiya1, Sumit Saha, Aliasgar F Shahiwala
1National Institute of Pharmaceutical Education and Research (NIPER)-Ahmedabad. C/o. B.V. Patel Pharmaceutical Education and Research Development Centre, S.G. Highway, Thaltej, Ahmedabad-380054, India.
Current Drug Delivery
|September 16, 2009
Summary
Mouth Dissolving Films (MDF) offer a convenient oral drug delivery system, improving patient compliance. This review explores polymers and plasticizers used in MDF manufacturing and their impact on film properties.
Area of Science:
- Pharmaceutical Sciences
- Drug Delivery Systems
Background:
- Patient compliance is crucial for effective drug therapy.
- Traditional oral dosage forms can pose challenges, especially for pediatric and geriatric populations.
- Fast dissolving drug delivery systems offer an alternative for improved medication adherence.
Purpose of the Study:
- To review polymers and plasticizers in Mouth Dissolving Films (MDF) manufacturing.
- To highlight the influence of these excipients on MDF physico-mechanical properties.
- To provide an overview of MDF formulation and associated manufacturing challenges.
Main Methods:
- Literature review of polymers and plasticizers for MDF.
- Analysis of the impact of excipients on MDF properties.
- Discussion of MDF formulation and manufacturing considerations.
Main Results:
- Various polymers and plasticizers can be utilized in MDF.
- Excipient selection significantly affects MDF disintegration, dissolution, and mechanical strength.
- Common formulation and manufacturing issues in MDF production were identified.
Conclusions:
- Mouth Dissolving Films (MDF) represent an innovative drug delivery system enhancing patient compliance.
- Careful selection of polymers and plasticizers is essential for optimizing MDF performance.
- Addressing formulation and manufacturing challenges is key to successful MDF development.
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