Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Heart Failure V: Medical Management01:30

Heart Failure V: Medical Management

Medical Management of Acute Decompensated Heart Failure (ADHF)The primary goals of therapy for patients hospitalized with acute decompensated heart failure (ADHF) include:Relieving symptomsOptimizing volume statusSupporting oxygenation and ventilationMaintaining cardiac output (CO) and end-organ perfusionIdentifying and addressing the cause of ADHFPreventing complicationsProviding patient education on factors precipitating HF exacerbationPlanning for dischargeOngoing monitoring and assessment...
Heart Failure Drugs: β-Blockers01:22

Heart Failure Drugs: β-Blockers

β-adrenergic antagonists, commonly known as β-blockers, block the effects of sympathetic neurotransmitters such as noradrenaline (NA) and adrenaline (ADR). They have several beneficial effects in heart failure treatment. They reduce heart rate, the force of contraction, and cardiac muscle relaxation. They also slow the atrial-ventricular conduction rate and raise the threshold for arrhythmias. The concentration of β-blockers determines their effects on bronchodilation, vasodilation, and...
Heart Failure Drugs: Inhibitors of Renin-Angiotensin System01:26

Heart Failure Drugs: Inhibitors of Renin-Angiotensin System

The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
Heart Failure Drugs: Diuretics01:22

Heart Failure Drugs: Diuretics

Heart failure and kidney perfusion are interconnected in a complex way. Reduced renal perfusion and venous congestion are two significant factors that contribute to renal dysfunction in heart failure. The kidneys, primarily responsible for fluid balance in the body, are adversely affected due to compromised cardiac output and increased venous pressure. In response to reduced renal perfusion, the kidneys activate neurohumoral mechanisms to restore balance. However, these mechanisms can be...
Heart Failure VI: Adjunct Therapies01:22

Heart Failure VI: Adjunct Therapies

Additional therapies for treating patients with heart failure (HF) may include procedural interventions, supplemental oxygen, the management of sleep disorders, and nutritional therapy.Procedural InterventionsImplantable Cardioverter-Defibrillator: For patients at risk of life-threatening arrhythmias due to severe left ventricular dysfunction, an Implantable Cardioverter-Defibrillator (ICD) can detect and terminate these arrhythmias, preventing sudden cardiac death and improving survival rates.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Enhanced recognition of ischemia by three variable analysis of the exercise stress test.

Journal of electrocardiology·2013
Same author

Advanced hybrid stress testing: a potential new paradigm combining exercise and pharmacologic stress.

Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology·2012
Same author

Intracardiac electrogram and ischemia alert.

Journal of the American College of Cardiology·2012
Same author

Lead aVR: dead or simply forgotten?

JACC. Cardiovascular imaging·2011
Same author

Usefulness of p-wave duration to identify myocardial ischemia during exercise testing.

The American journal of cardiology·2010
Same author

Exercise hypertension: an adverse prognosis?

Journal of the American Society of Hypertension : JASH·2010

Related Experiment Video

Updated: Jun 20, 2026

Reduction in Left Ventricular Wall Stress and Improvement in Function in Failing Hearts using Algisyl-LVR
07:24

Reduction in Left Ventricular Wall Stress and Improvement in Function in Failing Hearts using Algisyl-LVR

Published on: April 8, 2013

Point: a prescription to decrease left ventricular function.

Myrvin H Ellestad

    Preventive Cardiology
    |September 16, 2009
    PubMed
    Summary
    This summary is machine-generated.

    The Courage Trial found no difference in major events between invasive and conservative treatments for stable angina. However, conservative care may lead to progressive decline in left ventricular function.

    Related Experiment Videos

    Last Updated: Jun 20, 2026

    Reduction in Left Ventricular Wall Stress and Improvement in Function in Failing Hearts using Algisyl-LVR
    07:24

    Reduction in Left Ventricular Wall Stress and Improvement in Function in Failing Hearts using Algisyl-LVR

    Published on: April 8, 2013

    Area of Science:

    • Cardiology
    • Interventional Cardiology
    • Clinical Trials

    Background:

    • The Courage Trial (2007) evaluated invasive versus conservative therapy for stable angina with documented cardiac ischemia.
    • It randomized 2297 patients to assess major adverse events over 2.5 to 7 years.

    Discussion:

    • Myocardial biopsies show repeated ischemia causes fibrosis, mitochondrial loss, and impaired left ventricular function.
    • Ischemia can occur without angina, complicating assessment of treatment efficacy.
    • A significant crossover rate (32%) from conservative to invasive therapy was observed.

    Key Insights:

    • The study concluded that the routine opening of narrowed arteries (angioplasty) was not superior to conservative management for stable angina regarding major events.
    • Despite no difference in major events, conservative treatment might negatively impact long-term left ventricular function.

    Outlook:

    • Further research is needed to understand the long-term implications of conservative management on myocardial health.
    • The findings challenge the necessity of immediate revascularization in all stable ischemic heart disease patients.
    • Investigating optimal conservative strategies to preserve left ventricular function is crucial.