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Vision

Vision

Vision is the result of light being detected and transduced into neural signals by the retina of the eye. This information is then further analyzed and interpreted by the brain. First, light enters the front of the eye and is focused by the cornea and lens onto the retina—a thin sheet of neural tissue lining the back of the eye. Because of refraction through the convex lens of the eye, images are projected onto the retina upside-down and reversed.

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Related Experiment Video

Updated: Jun 20, 2026

Time-Lapse Imaging of Migrating Neurons and Glial Progenitors in Embryonic Mouse Brain Slices

Time-Lapse Imaging of Migrating Neurons and Glial Progenitors in Embryonic Mouse Brain Slices

Published on: March 8, 2024

Synaptogenesis in the developing mouse visual cortex.

Mingshan Li¹, Zhanjun Cui, Yanli Niu

¹Institute of Neurobiology and Laboratory of Neurobiology, Henan University, Kaifeng 475004, Henan Province, PR China.

Brain Research Bulletin

|September 16, 2009

Summary

This summary is machine-generated.

Synaptogenesis in the mouse visual cortex begins early but matures by postnatal day 7. Synapse maturation correlates with dendritic spine development and neocortex maturation.

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Last Updated: Jun 20, 2026

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Live Imaging of Mitosis in the Developing Mouse Embryonic Cortex

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Published on: June 4, 2014

Area of Science:

Neuroscience
Developmental Biology
Cell Biology

Background:

Synaptogenesis, the formation of synapses, is crucial for neural circuit development.
Understanding the ultrastructural changes during synaptogenesis provides insights into brain development and function.

Purpose of the Study:

To investigate the ultrastructural changes during synaptogenesis in the fetal and postnatal mouse visual cortex.
To correlate synapse maturation with dendritic spine development and synaptophysin expression.

Main Methods:

Transmission electron microscopy (TEM) for ultrastructural analysis.
Immunostaining to evaluate synaptophysin expression.
DiI dilakukan assay for dendritic spine development.

Main Results:

Immature nascent synapses were observed as early as embryonic day 15 (E15).
Synapse maturation, characterized by thickened membranes and a widened synaptic cleft, progressed gradually.
Ultrastructurally mature synapses (Gray's type I and II) were observed by postnatal day 7 (P7).
Synaptogenesis correlated with dendritic spine differentiation and synaptophysin expression.

Conclusions:

Synapse maturation in the mouse visual cortex is a progressive process.
Dendritic spine maturation and presynaptic vesicle component expression appear to be critical for synaptic specialization.
Synaptogenesis is closely linked to the overall development and maturation of the neocortex.