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Lipoprotein (a) levels in childhood arterial ischemic stroke

Serap Teber1, Gülhis Deda, Nejat Akar

  • 1Divisions of Pediatric Neurology, University of Ankara Faculty of Medicine, Ankara, Turkey. seraptteber@hotmail.com

Clinical and Applied Thrombosis/Hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
|September 16, 2009
PubMed

Insights

High lipoprotein (a) levels are prevalent in children with arterial ischemic stroke, suggesting it is a significant risk factor. Screening for lipoprotein (a) is recommended for pediatric stroke patients.

Area of Science:

  • Cardiovascular Science
  • Pediatric Neurology
  • Clinical Biochemistry

Background:

  • Lipoprotein (a) [Lp(a)] is a lipoprotein linked to cardiovascular disease.
  • Elevated Lp(a) is a known risk factor for stroke in adults.
  • Data on Lp(a) as a risk factor for pediatric ischemic stroke is limited.

Purpose of the Study:

  • To investigate the association between elevated lipoprotein (a) levels and arterial ischemic stroke in children.
  • To determine the prevalence of high Lp(a) in pediatric patients with arterial ischemic stroke.

Main Methods:

  • A case-control study involving 52 children with arterial ischemic stroke and 78 age- and sex-matched healthy controls.
  • Measurement of serum lipoprotein (a) levels in all participants.

Main Results:

  • 26.9% of children with arterial ischemic stroke exhibited high lipoprotein (a) levels.
  • This prevalence was significantly higher compared to the healthy control group.

Conclusions:

  • Elevated lipoprotein (a) is a significant risk factor for arterial ischemic stroke in children.
  • Lp(a) measurement should be considered in screening protocols for pediatric patients with arterial ischemic stroke and venous thromboembolism.
  • Incorporating Lp(a) testing alongside other thrombophilic factors can improve risk assessment in pediatric stroke.

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