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A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
06:01

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia

Published on: August 18, 2015

Polymorphisms associated with both noncardioembolic stroke and coronary heart disease: vienna stroke registry

May M Luke1, Wolfgang Lalouschek, Charles M Rowland

  • 1Celera, Alameda, California, USA. may.luke@celera.com

Cerebrovascular Diseases (Basel, Switzerland)
|September 16, 2009
PubMed

Insights

Genetic links between coronary heart disease (CHD) and noncardioembolic stroke risk were investigated. Four gene variants associated with CHD risk also showed association with noncardioembolic stroke risk in this study.

Area of Science:

  • Genetics
  • Cardiovascular Medicine
  • Neurology

Background:

  • Noncardioembolic stroke and coronary heart disease (CHD) may share common genetic factors.
  • Understanding these shared predispositions can inform risk assessment and prevention strategies.

Purpose of the Study:

  • To investigate the hypothesis that genetic variants associated with CHD risk are also associated with noncardioembolic stroke risk.
  • To identify specific gene variants that may confer risk for both conditions.

Main Methods:

  • A case-control study was conducted with 562 noncardioembolic stroke cases and 815 controls from the Vienna Stroke Registry.
  • Six gene variants previously associated with CHD risk in large studies were selected for analysis.
  • Association of these variants with noncardioembolic stroke risk was assessed using odds ratios and confidence intervals.

Main Results:

  • Four of the six selected gene variants showed an association with noncardioembolic stroke risk.
  • Specific variants and their odds ratios included rs3900940 in MYH15 (1.31), rs20455 in KIF6 (1.24), rs1010 in VAMP8 (1.21), and rs10757274 on chromosome 9p21 (1.20).

Conclusions:

  • Genetic predispositions may contribute to the shared risk between noncardioembolic stroke and coronary heart disease.
  • The identified gene variants represent potential shared etiological factors warranting further investigation.

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