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Tachycardia-Induced Cardiomyopathy As a Chronic Heart Failure Model in Swine
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Tachycardia-Induced Cardiomyopathy As a Chronic Heart Failure Model in Swine

Published on: February 17, 2018

Morbidity and prognostic factors in chronic chagasic cardiopathy

Manoel Otávio C Rocha1, Maria Carmo P Nunes, Antonio L Ribeiro

  • 1Programa de Pós-Graduação em Ciências da Saúde, Infectologia e Medicina Tropical, Departamento de Clínica Médica, Hospital das Clínicas, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brasil. rochamoc@medicina.ufmg.br

Memorias Do Instituto Oswaldo Cruz
|September 16, 2009
PubMed

Insights

Chagas heart disease prognosis is linked to left ventricular function and left atrial volume. Right ventricular dysfunction also predicts survival in heart failure patients with Chagas disease.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Echocardiography

Background:

  • Chagas disease presents complex clinical features.
  • Understanding morbidity and prognostic factors in Chagas heart disease is crucial.

Purpose of the Study:

  • To summarize recent research on morbidity and prognostic factors in Chagas heart disease.
  • To identify key indicators for ischemic cerebrovascular events and survival.

Main Methods:

  • Retrospective study design.
  • Doppler echocardiography for assessing ventricular function and volume.
  • Analysis of clinical data and conventional echocardiographic parameters.

Main Results:

  • Ischemic stroke with left ventricular (LV) apical thrombi is a frequent initial manifestation.
  • LV function and left atrial volume (LAV) independently predict cerebrovascular events.
  • Right ventricular (RV) dysfunction predicts survival, especially when associated with LV impairment.
  • LAV offers additional prognostic information beyond clinical and conventional echocardiographic data.

Conclusions:

  • LV function and LAV are critical for predicting cerebrovascular events in Chagas heart disease.
  • RV dysfunction is a significant predictor of survival in heart failure patients.
  • LAV provides valuable incremental prognostic data for survival prediction.

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