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Assays for the Specific Growth Rate and Cell-binding Ability of Rotavirus
Published on: January 28, 2019
Ancillary testing in children with rotavirus gastroenteritis.
Peter A Rowinsky1, Andrew P Steenhoff, Shiang-Ju Kung
1Department of Pediatrics, University of Washington School of Medicine, Seattle, Washington, USA.
Journal of Hospital Medicine
|September 16, 2009
Summary
In children with rotavirus gastroenteritis (RGE), serious bacterial infections (SBI) were not observed, questioning the need for costly tests. Younger children (≤6 months) faced longer hospital stays.
Area of Science:
- Pediatrics
- Infectious Diseases
- Clinical Microbiology
Background:
- Rotavirus gastroenteritis (RGE) is a common childhood illness.
- Microbiological assays are often used to rule out serious bacterial infections (SBI) in RGE patients.
- The incidence of concurrent SBI in RGE is largely unknown.
Purpose of the Study:
- To determine the incidence of SBI in children with RGE.
- To identify risk factors associated with prolonged hospitalization in this cohort.
Main Methods:
- Retrospective cohort study of children under 18 with laboratory-confirmed RGE.
- Data collected over a 4-year period at a community hospital.
- Prolonged length of stay (LOS) defined as hospitalization for ≥3 days.
Main Results:
- Ninety-four RGE cases were identified; 88.3% required admission.
- No cases of concurrent SBI were found.
- Age ≤6 months and peripheral blood culture collection were associated with prolonged LOS (≥3 days).
Conclusions:
- The absence of SBI in children with RGE suggests routine microbiological assays may be unnecessary.
- Younger children (≤6 months) are at higher risk for prolonged hospitalization.
- Findings may inform clinical practice regarding diagnostic testing and resource allocation.
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