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[Ketorolac vs metamizol preemptive analgesia in children]

Juana Peñuelas-Acuña1, S Alejandra Oriol-López, Clara E Hernández-Bernal

  • 1Servicio de Anestesiología, Fisiología y T, Respiratoria y Clinica del Dolor, del Hospital Juárez de México SS. penuelas@imx.inter.net

Cirugia Y Cirujanos
|September 17, 2009
PubMed

Insights

Ketorolac and metamizol effectively provided preventive analgesia in children undergoing surgery, with no significant differences between the two drugs. Both medications helped prevent post-surgical hyperalgesia without affecting blood counts or bleeding times.

Area of Science:

  • Pediatric Anesthesiology
  • Pharmacology

Background:

  • Preventive analgesia is crucial for managing post-surgical pain in children.
  • Non-opioid analgesics are preferred to minimize side effects.

Purpose of the Study:

  • To compare the efficacy of ketorolac and metamizol for preventive analgesia in pediatric surgery.
  • To evaluate the impact of these analgesics on post-operative pain and safety parameters.

Main Methods:

  • A prospective, randomized study involving 120 children aged 3-6 years undergoing various surgical procedures.
  • Intravenous administration of ketorolac or metamizol 15 minutes before surgery under inhaled general anesthesia.
  • Pain assessment using modified McGrath scales and chromatic EVA; monitoring of bleeding time, platelet count, and white blood cell count.

Main Results:

  • Both ketorolac and metamizol showed comparable efficacy in preventing post-surgical pain, with no statistically significant difference (p > 0.5).
  • 40% of children in both groups experienced no pain, and 55% reported mild to moderate pain.
  • No significant alterations were observed in bleeding time, platelet count, or white blood cell count.

Conclusions:

  • Ketorolac and metamizol are effective in providing preventive analgesia for pediatric surgical patients.
  • Both agents successfully prevent post-surgical hyperalgesia without adverse effects on hematological parameters or hemostasis.

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