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Related Experiment Video

Updated: Jun 20, 2026

Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression

Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression

Published on: June 15, 2019

Successes and lessons learned implementing the sepsis bundle.

Wayne E Soo Hoo¹, Kimberly Muehlberg, Richard G Ferraro

¹Mercy San Juan Medical Center, Carmichael, CA, USA. drsoohoo@aol.com

Journal for Healthcare Quality : Official Publication of the National Association for Healthcare Quality

|September 17, 2009

Summary

Sepsis care improvements significantly reduced preventable deaths and costs. Systematic changes in sepsis recognition and standardized treatment proved highly effective in saving lives and lowering expenses.

Related Experiment Videos

Last Updated: Jun 20, 2026

Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression

Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression

Published on: June 15, 2019

Area of Science:

Critical care medicine
Healthcare quality improvement
Public health

Background:

Sepsis is a major cause of preventable mortality in the US.
Variations in clinical practice and high costs per case were identified.

Observation:

An enterprise-wide initiative focused on reducing sepsis-related deaths.
Multidisciplinary teams were established at facilities to enhance sepsis care.

Findings:

Systematic improvements in sepsis recognition led to better patient outcomes.
Standardized sepsis care protocols significantly reduced mortality rates.
Direct variable costs associated with sepsis cases decreased substantially.

Implications:

The study highlights the potential for substantial reductions in sepsis mortality and costs.
Implementing standardized sepsis protocols is crucial for improving patient survival.
This approach offers a scalable model for healthcare systems aiming to improve sepsis management.