Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Retrovirus Life Cycles

Retrovirus Life Cycles

Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the retrovirus to...

Sexually Transmitted Infections

Sexually Transmitted Infections

Sexually transmitted infections (STIs) are diseases transmitted primarily through unsafe sexual interactions. Bacteria, viruses, or parasites cause them and can result in severe health complications if untreated.ChlamydiaThe bacterium Chlamydia trachomatis is responsible for the disease Chlamydia, the most common STI in the United States. This peculiar pathogen requires human cells to reproduce, residing intracellularly. The initial infection often goes unnoticed because it typically does not...

Pulmonary Tuberculosis I

Pulmonary Tuberculosis I

Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...

Aging

Aging

Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...

The Effect of Aging on Tissues

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...

Immunodeficiency Diseases

Immunodeficiency Diseases

Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency disorders...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Brief Report: Intracellular Cystatin B Levels Are Altered in HIV-Infected Participants With Respect to Neurocognitive Status and Antiretroviral Therapy.

Journal of acquired immune deficiency syndromes (1999)·2022

Same author

Changes in lipidomic profile by anti-retroviral treatment regimen: An ACTG 5257 ancillary study.

Medicine·2021

Same author

Physical activity trends and metabolic health outcomes in people living with HIV in the US, 2008-2015.

Progress in cardiovascular diseases·2020

Same author

Obesity Affects the Association of Bioelectrical Impedance Phase Angle With Mortality in People Living With HIV.

The Journal of the Association of Nurses in AIDS Care : JANAC·2019

Same author

HIV-1 latent reservoir size and diversity are stable following brief treatment interruption.

The Journal of clinical investigation·2018

Same author

Low-density lipoprotein cholesterol response after statin initiation among persons living with human immunodeficiency virus.

Journal of clinical lipidology·2018

Search research articles

Related Experiment Video

Updated: Jun 20, 2026

Oral Combinational Antiretroviral Treatment in HIV-1 Infected Humanized Mice

Oral Combinational Antiretroviral Treatment in HIV-1 Infected Humanized Mice

Published on: October 6, 2022

HIV and aging: two converging epidemics.

Nur F Onen¹, E Turner Overton

¹Infectious Diseases Division, Washington University School of Medicine, USA. nonen@dom.wustl.edu

Missouri Medicine

|September 17, 2009

Summary

This summary is machine-generated.

As the Human immunodeficiency virus (HIV) epidemic ages, older individuals face complex health challenges. Managing comorbidities like cardiovascular disease, cancer, and cognitive decline is crucial for this growing population.

More Related Videos

Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty

Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty

Published on: July 24, 2013

Exergaming in Older People Living with HIV Improves Balance, Mobility and Ameliorates Some Aspects of Frailty

Exergaming in Older People Living with HIV Improves Balance, Mobility and Ameliorates Some Aspects of Frailty

Published on: October 6, 2016

Related Experiment Videos

Last Updated: Jun 20, 2026

Oral Combinational Antiretroviral Treatment in HIV-1 Infected Humanized Mice

Oral Combinational Antiretroviral Treatment in HIV-1 Infected Humanized Mice

Published on: October 6, 2022

Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty

Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty

Published on: July 24, 2013

Exergaming in Older People Living with HIV Improves Balance, Mobility and Ameliorates Some Aspects of Frailty

Exergaming in Older People Living with HIV Improves Balance, Mobility and Ameliorates Some Aspects of Frailty

Published on: October 6, 2016

Area of Science:

Gerontology
Infectious Diseases
Public Health

Background:

The Human immunodeficiency virus (HIV) epidemic is aging, leading to a growing population of older adults living with HIV.
Older individuals with HIV often present with higher comorbidity burdens compared to younger populations.
The long-term effects of HIV infection and its treatment, combined with aging, pose significant health concerns.

Purpose of the Study:

To highlight the complex challenges in managing the health of the aging HIV-infected population.
To emphasize the increased prevalence of comorbidities in older adults with HIV.
To address the compounded impact of HIV, aging, and treatment on age-related diseases.

Main Methods:

This study is a review and synthesis of current knowledge regarding the aging HIV epidemic.
It analyzes the intersection of HIV, aging, and the development of comorbidities.
Focuses on the clinical and public health implications for older HIV-infected individuals.

Main Results:

Older persons living with HIV experience a greater burden of comorbidities.
There is a significant concern regarding the combined effects of HIV, aging, and treatment on cardiovascular disease, malignancies, cognitive impairment, depression, and frailty.
The incidence and prevalence of these conditions are increasing in the older HIV-positive population.

Conclusions:

Effective management strategies are needed to address the unique healthcare needs of the aging HIV population.
Further research is required to understand and mitigate the long-term consequences of HIV in older adults.
Multidisciplinary care approaches are essential for optimizing health outcomes in this demographic.