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Related Concept Videos

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Related Experiment Video

Updated: Jun 20, 2026

Genetic Mapping of Thermotolerance Differences Between Species of Saccharomyces Yeast via Genome-Wide Reciprocal Hemizygosity Analysis
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Published on: August 12, 2019

Genetic map refinement using a comparative genomic approach.

Denis Bertrand1, Mathieu Blanchette, Nadia El-Mabrouk

  • 1DIRO, Université de Montréal, Montréal, Quebec, Canada.

Journal of Computational Biology : a Journal of Computational Molecular Cell Biology
|September 17, 2009
PubMed
Summary
This summary is machine-generated.

This study develops a method to combine ambiguous genetic maps into a single, resolved map for each species. It uses phylogenetic information and heuristics to improve marker ordering in plant genomes.

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G2-seq: A High Throughput Sequencing-based Technique for Identifying Late Replicating Regions of the Genome

Published on: March 22, 2018

Area of Science:

  • Genomics
  • Bioinformatics
  • Computational Biology

Background:

  • Genetic mapping techniques produce multiple, sometimes ambiguous, gene orderings for species.
  • Ambiguous markers are represented as Directed Acyclic Graphs (DAGs), creating partial orders.
  • Phylogenetic relationships between species offer complementary information for map resolution.

Purpose of the Study:

  • To infer a single, highly resolved DAG for each species by integrating individual genetic maps.
  • To leverage phylogenetic tree information to improve marker order accuracy.
  • To develop and apply novel heuristics for ordering incomparable markers.

Main Methods:

  • Representing individual genetic maps as Directed Acyclic Graphs (DAGs).
  • Combining multiple DAGs at each leaf of a phylogenetic tree.
  • Employing breakpoint and Kemeny distance heuristics to order incomparable markers.
  • Applying algorithms to plant species data from the Gramene database.

Main Results:

  • Successfully generated more resolved genetic maps by integrating information from multiple sources.
  • Demonstrated the utility of phylogenetic context in refining gene order.
  • Evaluated the effectiveness of the developed ordering heuristics.

Conclusions:

  • The proposed method effectively resolves ambiguous marker orderings in genetic maps.
  • Integrating phylogenetic and genetic mapping data enhances map resolution.
  • The developed heuristics provide a robust approach for comparative genomics.