Related Experiment Video
Updated: Jun 20, 2026

Quantification of Endosome and Lysosome Motilities in Cultured Neurons Using Fluorescent Probes
Published on: May 22, 2017
The role of vesicle trafficking in epithelial cell motility
Sarah J Fletcher1, Joshua Z Rappoport
1School of Biosciences, University of Birmingham, Edgbaston, Birmingham, UK.
Abstract:
Cell motility is important for many physiological and pathological processes including organ development, wound healing, cancer metastasis and correct immune responses. In particular, epithelial wound healing is both a medically relevant topic and a common experimental model. Mechanisms underlying generation of a polarized cell and maintenance of a motile phenotype during steady-state migration are not well understood. Polarized trafficking of bulk membrane and cell adhesion molecules has been implicated in regulation of cell motility. The present review focuses on the role of different trafficking pathways in epithelial cell migration, including clathrin-mediated endocytosis, caveolar endocytosis, exocytosis of biosynthetic cargo, 'short-loop' and 'long-loop' endosomal recycling.
Related Concept Videos
The Movement of Organelles and Vesicles
Clathrin Coated Vesicles
Vesicular Tubular Clusters
With the help of motor proteins such...
Introduction to Membrane Traffic
The transport of soluble and membrane proteins is mediated by transport vesicles that collect cargo from one cellular compartment and deliver it to another by fusing with the target organelle membrane. The Rab...
Role of Myosin in Cell Migration
Myosin II is a hexamer comprising two heavy chains with globular heads and coiled-coil tails, two regulatory light chains, and two essential light chains. The ATPase sites on the myosin heads hydrolyze ATP, and the released phosphate generates the force for contraction. It is...
Cell Motility through Blebbing
Blebbing Through the Matrix
In multicellular...
