Influence of splitting on dissolution properties of metoprolol tablets
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Updated: Jun 20, 2026

Formation of Dispersible Taohong Siwu Tablets
Published on: February 3, 2023
1Department of Pharmaceutical Technology, University of Sarajevo, Bosnia and Herzegovina.
Abstract:
The objective of this work was to compare several profiles of dissolution data for metoprolol controlled release tablet formulations in order to identify possible changes in dissolution profiles of whole and scored tablets. Adequate design of score lines (on one or both sides) as well as the technology of preparation of tablet mixtures ensure forming a score line of adequate thickness, shape, size, curvature. According to the obtained results, this type of extended release formulation is eligible for splitting and use in therapy either as a whole or scored tablets.
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