Adrenergic dependence of the platelet aggregation in rats

The paper examines the effect of different adrenergic agents influencing both the neuronal unit of the adrenergic transmitter system and its alpha- and beta-receptor components on the ADP-induced platelet aggregation. A considerable inhibition of the platelet aggregation is found under conditions of post-reserpine adrenergic block (16.06%, p less than 0.001) and blocking of the beta 1-adrenergic receptors with practolol, applied independently (45.06%, p less than 0.001) and prior to the treatment of the rats with dobutamine--beta 1-adrenoreceptor agonist (52.20%, p less than 0.001). The stimulation of these receptors with dobutamine accelerates the platelet aggregation by 41.04% (p less than 0.001). No changes in the platelet aggregation are found after treatment with phenoxybenzamine (nonselective alpha adrenergic blocker) and salbutamol (beta 2-adrenergic agonist). It may be concluded that the ADP-induced platelet aggregation depends to a certain extent on the functional state of the neuronal and beta-adrenoreceptor unit of the adrenergic transmitter system and possibly also on the metabolic processes connected with them.