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Blood pressure control and components of the metabolic syndrome: the GOOD survey

Walter Zidek1, Lisa Naditch-Brûlé, Stefano Perlini

  • 1Medizinische Klinik IV (Endocrinology and Nephrology), Charité, Berlin, Germany. walter.zidek@charite.de

Cardiovascular Diabetology
|September 17, 2009
PubMed

Insights

Metabolic syndrome components like visceral obesity and dyslipidemia, specifically high triglycerides and low HDL cholesterol, are linked to poor blood pressure control in hypertensive patients. Impaired glucose tolerance is not the primary driver of this resistance to treatment.

Area of Science:

  • Cardiology
  • Endocrinology
  • Metabolic Disorders

Background:

  • Hypertensive patients with metabolic syndrome or diabetes exhibit worse blood pressure control.
  • The Global Cardiometabolic Risk Profile in Patients with Hypertension Disease (GOOD) survey highlighted this disparity.
  • This study investigates specific metabolic syndrome components contributing to poor blood pressure control.

Purpose of the Study:

  • To identify which components of metabolic syndrome are most strongly associated with inadequate blood pressure control.
  • To differentiate the impact of metabolic syndrome and diabetes mellitus on hypertension management.
  • To guide targeted therapeutic strategies for hypertensive patients with metabolic abnormalities.

Main Methods:

  • Observational, cross-sectional survey (GOOD survey) across 12 European countries.
  • Inclusion of 3,280 outpatients with hypertension receiving treatment or newly diagnosed.
  • Comparison of blood pressure control, BMI, waist circumference, triglycerides, and HDL cholesterol across defined patient groups.

Main Results:

  • Patients with metabolic syndrome (with or without diabetes) showed the highest blood pressure values.
  • Patients with diabetes mellitus alone had significantly lower blood pressure compared to those with metabolic syndrome.
  • Metabolic syndrome was associated with higher BMI, waist circumference, triglycerides, and lower HDL cholesterol.

Conclusions:

  • Visceral obesity and dyslipidemia (high triglycerides, low HDL cholesterol) are key drivers of antihypertensive treatment resistance.
  • Impaired glucose tolerance, a component of metabolic syndrome, is not significantly associated with poor blood pressure control.
  • Targeting obesity and lipid profiles may improve blood pressure management in hypertensive patients with metabolic syndrome.
Abstract

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