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Disparities in cancer clinical trials: an analysis of comprehensive cancer control plans
Tisha Moniek Felder1, Gabriela D Pena, Bridget F Chapital
1Center for Health Promotion and Prevention Research, University of Texas School of Public Health, University of Texas Health Science Center-Houston, Houston, TX 77030, USA. Tisha.M.Felder@uth.tmc.edu
Introduction:
Disparities in enrollment of adults in cancer clinical trials are well documented, but little is known about the attention given to this topic in comprehensive cancer control (CCC) plans. We assessed the extent to which CCC plans address disparities in clinical trials and whether jurisdictions whose plans address disparities also mandate third-party reimbursement for clinical trial participation.
Methods:
We analyzed 57 CCC plans identified from Cancer PLANET (Plan, Link, Act, Network with Evidence-based Tools) and Cancerplan.org from April through December 2007. We searched plans for general and disparity-specific content regarding clinical trials and analyzed the content for emergent themes. We assessed frequencies of themes, patterns between themes, and patterns between themes and laws. We reviewed third-party reimbursement laws, as of September 2007, as recorded by the National Cancer Institute's State Cancer Legislative Database.
Results:
Fifty-five (96%) CCC plans had content regarding clinical trials. Of the 39 (71%) plans that specifically addressed disparities, 13 (33%) were in a state with laws mandating third-party reimbursement. Increasing participation and education, awareness, and outreach were the most common themes identified.
Conclusion:
Although many CCC plans address disparities in clinical trials, few of those plans are in jurisdictions that have third-party reimbursement laws.
Insights
Comprehensive cancer control plans often address clinical trial disparities, but few states with such plans mandate third-party reimbursement for trial participation. This highlights a gap in supporting equitable access to cancer research.
Area of Science:
- Public Health
- Cancer Control
- Health Policy
Background:
- Disparities in adult cancer clinical trial enrollment are significant.
- The attention given to these disparities in comprehensive cancer control (CCC) plans is not well understood.
Purpose of the Study:
- To assess how CCC plans address cancer clinical trial disparities.
- To determine if CCC plans addressing disparities are linked to third-party reimbursement laws for clinical trial participation.
Main Methods:
- Analysis of 57 CCC plans from Cancer PLANET and Cancerplan.org (2007).
- Content analysis of plans for themes related to clinical trials and disparities.
- Review of state third-party reimbursement laws for clinical trials (as of 2007).
Main Results:
- 96% of CCC plans included content on clinical trials.
- 71% of plans specifically addressed disparities.
- Only 33% of plans addressing disparities were in states with third-party reimbursement laws.
Conclusions:
- Many CCC plans acknowledge disparities in cancer clinical trials.
- A significant gap exists between addressing disparities in plans and having supportive reimbursement policies.
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