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Related Experiment Video

Updated: Jun 20, 2026

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

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Published on: August 30, 2018

Rational antibiotic use.

Ozlem Tunger¹, Yeliz Karakaya, C Banu Cetin

¹Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Celal Bayar University, Manisa, Turkey. otunger@hotmail.com

Journal of Infection in Developing Countries

|September 17, 2009

Summary

Turkey's antibiotic restriction policy significantly reduced overall antibiotic use and increased rational prescribing. This governmental intervention, reinforced by infectious disease specialists, proved effective in optimizing antimicrobial therapy and lowering costs.

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Area of Science:

Infectious Diseases
Public Health Policy
Antimicrobial Stewardship

Background:

Antimicrobial resistance and escalating costs due to inappropriate antibiotic use pose global health challenges.
Antibiotic restriction policies are implemented to optimize antimicrobial therapy and reduce healthcare expenditures.
A governmental antibiotic restriction policy was introduced in Turkey in 2003 to curb antibiotic consumption and associated costs.

Purpose of the Study:

To evaluate the rational use of antibiotics in a hospital setting.
To assess the impact of a national antibiotic restriction policy, supported by infectious disease specialists, on hospital-wide antibiotic utilization.

Main Methods:

A comparative study analyzing inpatient antibiotic data from January-June 2006 (post-policy) against data from 1998 (pre-policy).
Prospective daily surveillance of patients receiving antibiotics was conducted by three infectious disease specialists in both study periods.
Appropriateness of antibiotic therapy was assessed using established criteria (Kunin and Jones), with data analyzed using SPSS for Windows.

Main Results:

Antibiotic use decreased from 16.6% to 11.3% after the restriction policy implementation (p<0.001).
Rational antibiotic use significantly increased post-policy (p<0.001), with a notable decrease in prophylactic antibiotic use.
Infectious disease specialist involvement led to a documented increase in appropriate antibiotic prescriptions.

Conclusions:

The implemented antibiotic restriction policy was effective in reducing overall antibiotic consumption.
The policy successfully enhanced the rate of rational antibiotic prescription within the hospital.
Reinforcement by infectious disease specialists played a crucial role in the policy's success.