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Updated: Jun 20, 2026

Modeling Oral-Esophageal Squamous Cell Carcinoma in 3D Organoids
Published on: December 23, 2022
[A case of superficial small cell carcinoma of the esophagus]
Masashi Hirota1, Etsuko Nakamura, Katsuya Yamashita
1Dept. of Surgery, National Hospital Organization Toyohashi Medical Center.
Abstract:
A 69-year-old man complaining of odynophagia visited a nearby hospital, and was referred to our hospital with endoscopic findings showing a flat-elevated lesion 35 cm from the incisors. Biopsy in our hospital revealed small cell carcinoma with a squamous cell carcinoma component. Thoracoabdominal enhanced CT detected neither lymph node metastases, nor distant organ metastases. We selected subtotal esophagectomy and retrosternal reconstruction of gastric tube. Since small cell carcinoma of the esophagus has a dismal prognosis, we conducted a minimally invasive operation with two-field lymph node dissection from the standpoint of local treatment, then shifted early to postoperative chemotherapy. The pathological diagnosis was an undifferentiated carcinoma, small cell type, inf beta, pT1b (pSM), ie (-), ly0, v1, pIM0, pN0. Postoperatively, he underwent chemotherapy with CDDP+CPT-11 following small cell carcinoma of the lung. Here mains alive without evidence of recurrence in the two years three months since the operation.
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