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Related Concept Videos

Peptic Ulcer Disease IV: Management01:26

Peptic Ulcer Disease IV: Management

Medical treatment strategies for peptic ulcers encompass various methods. The primary goal of treatment is to diminish gastric acidity and strengthen mucosal defense mechanisms.
The therapeutic approach involves ensuring adequate rest, implementing drug therapy, promoting smoking cessation, making dietary modifications, and emphasizing long-term follow-up care.
Pharmacological management
The prevailing therapy for peptic ulcers involves a combination of managing the patient's current medication...
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Hand hygiene

Asepsis is the practice of preventing or breaking the chain of infection. The nurse employs aseptic techniques to prevent the spread of microorganisms and reduce the risk of diseases. Hand hygiene is the cornerstone of aseptic techniques and is classified into medical and surgical asepsis. Medical asepsis includes hand hygiene and the use of gloves. Surgical asepsis, or the sterile technique, refers to practices that render and keep objects and areas free of microorganisms.
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Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
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Treatment for Pulmonary Arterial Hypertension: Endothelin Receptor Antagonists01:18

Treatment for Pulmonary Arterial Hypertension: Endothelin Receptor Antagonists

Endothelins (ETs) are potent vasoactive peptides critical in the human body's various physiological and pathological processes. One of the most promising therapeutic strategies for treating pulmonary arterial hypertension (PAH) involves counteracting the effects of these endothelins using a class of drugs known as endothelin receptor antagonists.
ETs are synthesized through a complex sequence of enzymatic steps, primarily involving an enzyme referred to as endothelin-converting enzyme (ECE). Of...
Treatment for Pulmonary Arterial Hypertension: Phosphodiesterase Inhibitors01:28

Treatment for Pulmonary Arterial Hypertension: Phosphodiesterase Inhibitors

Phosphodiesterase 5 (PDE5) inhibitors are potent enzymes that function to hydrolyze cyclic nucleotides to their corresponding 5' monophosphates. Their unique biochemical properties have been applied in treating Pulmonary Arterial Hypertension (PAH).
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Treatment for Pulmonary Arterial Hypertension: Prostacyclin Receptor Agonists

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Related Experiment Video

Updated: Jun 20, 2026

Technique of Conjunctival Biopsy and Direct Immunofluorescence for Diagnosing Mucous Membrane Pemphigoid
05:05

Technique of Conjunctival Biopsy and Direct Immunofluorescence for Diagnosing Mucous Membrane Pemphigoid

Published on: June 17, 2025

Treatment options in pemphigus.

J C Bystryn1, N Habib

  • 1The Ronald O. Perelman Department of Dermatology, The New York University School of Medicine, New York, NY, USA. bystryn@nyu.edu

Giornale Italiano Di Dermatologia E Venereologia : Organo Ufficiale, Societa Italiana Di Dermatologia E Sifilografia
|September 17, 2009
PubMed
Summary
This summary is machine-generated.

Pemphigus treatment has greatly improved survival rates, but challenges persist in reducing mortality and medication side effects. New biological therapies like rituximab offer promise for inducing remission in difficult cases.

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Granulocyte-dependent Autoantibody-induced Skin Blistering
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Granulocyte-dependent Autoantibody-induced Skin Blistering

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Technique of Conjunctival Biopsy and Direct Immunofluorescence for Diagnosing Mucous Membrane Pemphigoid
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Granulocyte-dependent Autoantibody-induced Skin Blistering
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Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

Area of Science:

  • Dermatology
  • Immunology
  • Internal Medicine

Background:

  • Pemphigus therapy has evolved significantly, reducing mortality from an almost invariably fatal disease to approximately 5%.
  • Despite advances, significant challenges remain in further decreasing pemphigus mortality and mitigating severe medication side effects.
  • Systemic steroids are the current cornerstone of pemphigus treatment.

Purpose of the Study:

  • To review the current state of pemphigus therapy.
  • To discuss the role of adjuvant therapies and newer biological agents.
  • To highlight ongoing challenges and future directions in pemphigus management.

Main Methods:

  • Review of existing literature on pemphigus treatment modalities.
  • Analysis of the efficacy and safety of systemic steroids, adjuvant drugs, and biological therapies.
  • Discussion of clinical trial data and evidence for treatment effectiveness.

Main Results:

  • Systemic steroids remain the primary treatment, but their side effects are a concern.
  • The effectiveness of adjuvant "steroid-sparing" agents lacks robust randomized trial data.
  • Biologicals like IVIg and rituximab show promise in controlling active disease and inducing remission.

Conclusions:

  • While pemphigus treatment has seen remarkable success, further improvements in mortality and side effect profiles are needed.
  • Adjuvant therapies require more rigorous investigation to establish their role.
  • Biological therapies represent a significant advancement, particularly rituximab for achieving complete clinical remission.