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Structural and functional constraints in the evolution of protein families

Catherine L Worth1, Sungsam Gong, Tom L Blundell

  • 1Biochemistry Department, University of Cambridge, UK.

Nature Reviews. Molecular Cell Biology
|September 17, 2009
PubMed

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Protein families are groups of homologous proteins; that is, they have similarities in amino acid sequences and three-dimensional structures. Protein families usually occur because of gene duplication, where an additional copy of a gene is inserted into the genome of an organism.   Mutations that change the amino acids but still allow the protein to be properly synthesized, will lead to new protein family members.   If these new proteins contain similar amino acids in key locations, protein...
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Conserved Binding Sites01:49

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